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• W2085757191 abstract "McKim DA, Katz SL, Barrowman N, Ni A, LeBlanc C. Lung volume recruitment slows pulmonary function decline in Duchenne muscular dystrophy. Objective To evaluate the long-term effect on measures of forced vital capacity (FVC) before and after the introduction of regular lung volume recruitment (LVR) maneuvers (breath-stacking) in individuals with Duchenne muscular dystrophy (DMD). Design Retrospective cohort study of pulmonary function data, including FVC, cough peak flow (CPF), maximum inspiratory pressure (MIP), and maximum expiratory pressure (MEP). Data were collected for 33 months prior to and 45 months after LVR introduction. Setting Ambulatory care in a tertiary level regional rehabilitation center in Canada. Participants All individuals (N=22) with DMD (mean age ± SD, 19.6±2.4y), who were prescribed LVR and reported adherence with therapy. Interventions Introduction of regular LVR (breath-stacking); 3 to 5 maximal lung inflations (maximum insufflation capacity [MIC]) using a hand-held resuscitation bag and mouthpiece, twice daily. Main Outcome Measures Measures included the rate of decline of FVC in percent-predicted, before and after the introduction of regular LVR. Changes in maximum pressures (MIP, MEP), MIC, and cough peak flows were also measured. Results At LVR initiation, FVC was 21.8±16.9 percent-predicted, and cough peak flows were <270L/min (144.8±106.9L/min). Annual decline of FVC was 4.7 percent-predicted a year before LVR and 0.5 percent-predicted a year after LVR initiation. The difference, 4.2 percent-predicted a year (95% confidence interval, 3.5–4.9; P<.000), represents an 89% improvement in the annual rate of FVC decline. Conclusions The rate of FVC decline in DMD patients improves dramatically with initiation of regular LVR." @default.
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• W2085757191 date "2012-07-01" @default.
• W2085757191 modified "2023-10-16" @default.
• W2085757191 title "Lung Volume Recruitment Slows Pulmonary Function Decline in Duchenne Muscular Dystrophy" @default.
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• W2085757191 doi "https://doi.org/10.1016/j.apmr.2012.02.024" @default.
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