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- W2085758614 abstract "Clegg J. A. and Smithers S. R., 1972. The effect of immune rhesus monkey serum on schistosomula of Schistosoma mansoni during cultivation in vitro. International journal for Parasitology2: 79–98. The sera of rhesus monkeys hyperimmunized by 2–4 exposures to S. mansoni cercariae contain an antibody lethal to schistosomula cultivated in vitro. The antibody (IgG) is dependent on labile factors in fresh monkey serum. It can be absorbed by adult worms cultivated in vitro and it is not the antibody responsible for CHR or COP reactions. A titre of lethal antibody sufficient to kill all schistosomula in vitro is maintained for 2–3 months following challenge: it then falls to a moderate level which may be retained for several years. After inactivation, hyperimmune serum inhibits the growth of cultured schistosomula but does not kill them. Following a small primary infection rhesus serum develops a marked growth-inhibiting property and a low titre of lethal antibody at about 4 months, i.e. the time when resistance to reinfection can first be reliably demonstrated. After 5 days in cultures containing normal monkey serum and rbc or 4 days in a normal mouse, schistosomula are protected against the lethal and growth inhibiting effects of hyperimmune serum. This phenomenon is probably related to concomitant immunity and may be due to acquisition of host antigens." @default.
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- W2085758614 date "1972-03-01" @default.
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- W2085758614 title "The effects of immune rhesus monkey serum on schistosomula of Schistosoma mansoni during cultivation in vitro" @default.
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- W2085758614 doi "https://doi.org/10.1016/0020-7519(72)90036-7" @default.
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