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- W2085765428 abstract "Friend murine erythroleukemia (MEL) cells are transformed erythroid precursors that are held in an immature and proliferating state but can be induced to differentiate in vivo by treatment with a variety of chemical agents such as N, N-hexamethylene bisacetamide (HMBA). To investigate the role of Myb proteins in maintaining MEL cells in an immature and proliferating state we have produced stable transfectants in the C19 MEL cell line that contain a dominant interfering Myb allele (MEnT) under the control of an inducible mouse metallothionein I promoter. When expression of MEnT protein was induced with ZnCl2, the stable transfectants differentiated with kinetics that were similar to wild type C19 MEL cells treated with HMBA, including induction of alpha-globin mRNA expression, assembly of hemoglobin and growth arrest. Expression of endogenous c-myb and c-myc was also decreased in response to MEnT. Expression of mad-1 mRNA was rapidly increased in response to expression of MEnT resulting in a shift from predominantly c-Myc/Max complexes to predominantly Mad/Max containing complexes. These results strongly suggest that C19 MEL cells are held in an immature and proliferating state by a pathway that is dependent on Myb activity." @default.
- W2085765428 created "2016-06-24" @default.
- W2085765428 creator A5037650934 @default.
- W2085765428 creator A5046564576 @default.
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- W2085765428 date "2002-03-13" @default.
- W2085765428 modified "2023-10-17" @default.
- W2085765428 title "A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state" @default.
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- W2085765428 doi "https://doi.org/10.1038/sj.onc.1205003" @default.
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