Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085768223> ?p ?o ?g. }
- W2085768223 endingPage "13364" @default.
- W2085768223 startingPage "13360" @default.
- W2085768223 abstract "The rat enhancer of split- and hairy-related protein-1 (SHARP-1) is an insulin-inducible transcriptional repressor. In this study, we examined issues of whether (−)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, regulates the expression of the rat SHARP-1 gene and which signaling pathway mediates the regulation. When H4IIE cells were treated with EGCG, SHARP-1 mRNA levels rapidly increased. Pretreatments with inhibitors for either phosphoinositide 3-kinase (PI 3-K) or protein kinase C partially blocked EGCG induction. Atypical protein kinase C lambda (aPKCλ) is known as a downstream target of PI 3-K in the liver. When a dominant–negative form of aPKCλ was expressed, the EGCG-induced SHARP-1 mRNAs was inhibited. Finally, Western blot analysis revealed that EGCG rapidly and temporarily stimulates aPKCλ phosphorylation. Thus, we conclude that EGCG induces SHARP-1 gene expression via a PI 3-K/aPKCλ signaling pathway." @default.
- W2085768223 created "2016-06-24" @default.
- W2085768223 creator A5006756526 @default.
- W2085768223 creator A5009671084 @default.
- W2085768223 creator A5018788282 @default.
- W2085768223 creator A5034311639 @default.
- W2085768223 creator A5063689833 @default.
- W2085768223 creator A5064758344 @default.
- W2085768223 creator A5075234955 @default.
- W2085768223 creator A5087766035 @default.
- W2085768223 date "2011-11-30" @default.
- W2085768223 modified "2023-10-13" @default.
- W2085768223 title "(−)-Epigallocatechin-3-gallate Enhances the Expression of an Insulin-Inducible Transcription Factor Gene via a Phosphoinositide 3-Kinase/Atypical Protein Kinase C Lambda Pathway" @default.
- W2085768223 cites W1482685280 @default.
- W2085768223 cites W1971316445 @default.
- W2085768223 cites W1972868257 @default.
- W2085768223 cites W1975955075 @default.
- W2085768223 cites W1978787271 @default.
- W2085768223 cites W1997337342 @default.
- W2085768223 cites W2000012280 @default.
- W2085768223 cites W2021667186 @default.
- W2085768223 cites W2035313943 @default.
- W2085768223 cites W2036927231 @default.
- W2085768223 cites W2077633291 @default.
- W2085768223 cites W2077976952 @default.
- W2085768223 cites W2079829067 @default.
- W2085768223 cites W2080944114 @default.
- W2085768223 cites W2119483052 @default.
- W2085768223 cites W2127688015 @default.
- W2085768223 cites W2135909028 @default.
- W2085768223 cites W2147207624 @default.
- W2085768223 cites W4239759145 @default.
- W2085768223 cites W4246431465 @default.
- W2085768223 cites W4300379228 @default.
- W2085768223 doi "https://doi.org/10.1021/jf204016k" @default.
- W2085768223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22085033" @default.
- W2085768223 hasPublicationYear "2011" @default.
- W2085768223 type Work @default.
- W2085768223 sameAs 2085768223 @default.
- W2085768223 citedByCount "9" @default.
- W2085768223 countsByYear W20857682232012 @default.
- W2085768223 countsByYear W20857682232015 @default.
- W2085768223 countsByYear W20857682232017 @default.
- W2085768223 countsByYear W20857682232020 @default.
- W2085768223 crossrefType "journal-article" @default.
- W2085768223 hasAuthorship W2085768223A5006756526 @default.
- W2085768223 hasAuthorship W2085768223A5009671084 @default.
- W2085768223 hasAuthorship W2085768223A5018788282 @default.
- W2085768223 hasAuthorship W2085768223A5034311639 @default.
- W2085768223 hasAuthorship W2085768223A5063689833 @default.
- W2085768223 hasAuthorship W2085768223A5064758344 @default.
- W2085768223 hasAuthorship W2085768223A5075234955 @default.
- W2085768223 hasAuthorship W2085768223A5087766035 @default.
- W2085768223 hasConcept C104317684 @default.
- W2085768223 hasConcept C150194340 @default.
- W2085768223 hasConcept C153911025 @default.
- W2085768223 hasConcept C184235292 @default.
- W2085768223 hasConcept C185592680 @default.
- W2085768223 hasConcept C195794163 @default.
- W2085768223 hasConcept C2781322055 @default.
- W2085768223 hasConcept C55493867 @default.
- W2085768223 hasConcept C62478195 @default.
- W2085768223 hasConcept C75217442 @default.
- W2085768223 hasConcept C82495950 @default.
- W2085768223 hasConcept C86803240 @default.
- W2085768223 hasConcept C95444343 @default.
- W2085768223 hasConcept C97029542 @default.
- W2085768223 hasConceptScore W2085768223C104317684 @default.
- W2085768223 hasConceptScore W2085768223C150194340 @default.
- W2085768223 hasConceptScore W2085768223C153911025 @default.
- W2085768223 hasConceptScore W2085768223C184235292 @default.
- W2085768223 hasConceptScore W2085768223C185592680 @default.
- W2085768223 hasConceptScore W2085768223C195794163 @default.
- W2085768223 hasConceptScore W2085768223C2781322055 @default.
- W2085768223 hasConceptScore W2085768223C55493867 @default.
- W2085768223 hasConceptScore W2085768223C62478195 @default.
- W2085768223 hasConceptScore W2085768223C75217442 @default.
- W2085768223 hasConceptScore W2085768223C82495950 @default.
- W2085768223 hasConceptScore W2085768223C86803240 @default.
- W2085768223 hasConceptScore W2085768223C95444343 @default.
- W2085768223 hasConceptScore W2085768223C97029542 @default.
- W2085768223 hasIssue "24" @default.
- W2085768223 hasLocation W20857682231 @default.
- W2085768223 hasLocation W20857682232 @default.
- W2085768223 hasOpenAccess W2085768223 @default.
- W2085768223 hasPrimaryLocation W20857682231 @default.
- W2085768223 hasRelatedWork W1986526737 @default.
- W2085768223 hasRelatedWork W1987603245 @default.
- W2085768223 hasRelatedWork W1991032022 @default.
- W2085768223 hasRelatedWork W2004726042 @default.
- W2085768223 hasRelatedWork W2009966535 @default.
- W2085768223 hasRelatedWork W2021663631 @default.
- W2085768223 hasRelatedWork W2113044594 @default.
- W2085768223 hasRelatedWork W2123013129 @default.
- W2085768223 hasRelatedWork W2413650995 @default.
- W2085768223 hasRelatedWork W4248833308 @default.
- W2085768223 hasVolume "59" @default.
- W2085768223 isParatext "false" @default.