Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085778837> ?p ?o ?g. }
- W2085778837 endingPage "309" @default.
- W2085778837 startingPage "303" @default.
- W2085778837 abstract "Recent research has indicated that mitochondrial adenosine triphosphate-sensitive potassium channels play an important role in cerebral protection, which involves in attenuating the calcium of mitochondria. However, the effect of diazoxide on cerebral ischemia-reperfusion and the role of spermine, the agonist of mitochondrial calcium uniporter (MCU), remain unknown.We investigated the effect of MCU opener spermine on diazoxide against focal cerebral ischemia-reperfusion injury in rats.Adult male Wistar rats were randomly divided into 5 groups: the Sham group, the I/R group, the Dzx + I/R group, the Dzx + Sper + I/R group, and the Sper + I/R group. Rats were exposed to 2-hour ischemia and 24-hour reperfusion. Diazoxide were administrated 30 minutes before ischemia, and spermine were given 10 minutes before reperfusion. Rats in the Sham group did not experience the process of ischemia-reperfusion. After 24-hour reperfusion, rats were given neurological performance tests, overdosed with general anesthesia, and then their brains were excised for infarct volume, pathological changes, and biochemical evaluation and analysis.Rats in the Dzx + I/R group displayed improved neurological deficits and decreased infarct volume and oxidative stress (evidenced by decreased nitric oxide and malondialdehyde but increased antioxidant enzymes [eg, glutathione peroxide and superoxide dismutase]) caused by ischemia-reperfusion. The beneficial effects of diazoxide were significantly attenuated by spermine treatment. Rats in the Sper + I/R group displayed worse neurological deficits, larger infarct volume and more oxidative stress, and less antioxidant enzymes than those in the Dzx + I/R.Our results suggested that diazoxide, which improved neurological deficits and decreased infarct volume and oxidative stress against ischemia-reperfusion injury, is mediated by spermine." @default.
- W2085778837 created "2016-06-24" @default.
- W2085778837 creator A5023278223 @default.
- W2085778837 creator A5026400506 @default.
- W2085778837 creator A5039843021 @default.
- W2085778837 creator A5050986709 @default.
- W2085778837 creator A5058539392 @default.
- W2085778837 date "2014-02-01" @default.
- W2085778837 modified "2023-09-30" @default.
- W2085778837 title "The Effect of Mitochondrial Calcium Uniporter Opener Spermine on Diazoxide against Focal Cerebral Ischemia—Reperfusion Injury in Rats" @default.
- W2085778837 cites W1538399032 @default.
- W2085778837 cites W1543560706 @default.
- W2085778837 cites W1971034264 @default.
- W2085778837 cites W2006380004 @default.
- W2085778837 cites W2013900800 @default.
- W2085778837 cites W2022786377 @default.
- W2085778837 cites W2048519580 @default.
- W2085778837 cites W2065949088 @default.
- W2085778837 cites W2082425573 @default.
- W2085778837 cites W2085502084 @default.
- W2085778837 cites W2090298199 @default.
- W2085778837 cites W20938713 @default.
- W2085778837 cites W2112505121 @default.
- W2085778837 cites W2126544267 @default.
- W2085778837 cites W2135793165 @default.
- W2085778837 cites W2159305277 @default.
- W2085778837 cites W2371948111 @default.
- W2085778837 cites W82531269 @default.
- W2085778837 doi "https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.02.020" @default.
- W2085778837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23540254" @default.
- W2085778837 hasPublicationYear "2014" @default.
- W2085778837 type Work @default.
- W2085778837 sameAs 2085778837 @default.
- W2085778837 citedByCount "15" @default.
- W2085778837 countsByYear W20857788372014 @default.
- W2085778837 countsByYear W20857788372015 @default.
- W2085778837 countsByYear W20857788372016 @default.
- W2085778837 countsByYear W20857788372017 @default.
- W2085778837 countsByYear W20857788372018 @default.
- W2085778837 countsByYear W20857788372020 @default.
- W2085778837 countsByYear W20857788372023 @default.
- W2085778837 crossrefType "journal-article" @default.
- W2085778837 hasAuthorship W2085778837A5023278223 @default.
- W2085778837 hasAuthorship W2085778837A5026400506 @default.
- W2085778837 hasAuthorship W2085778837A5039843021 @default.
- W2085778837 hasAuthorship W2085778837A5050986709 @default.
- W2085778837 hasAuthorship W2085778837A5058539392 @default.
- W2085778837 hasConcept C126322002 @default.
- W2085778837 hasConcept C134018914 @default.
- W2085778837 hasConcept C181199279 @default.
- W2085778837 hasConcept C185592680 @default.
- W2085778837 hasConcept C2775838275 @default.
- W2085778837 hasConcept C2776109719 @default.
- W2085778837 hasConcept C2776151105 @default.
- W2085778837 hasConcept C2778401633 @default.
- W2085778837 hasConcept C2779306644 @default.
- W2085778837 hasConcept C2779872217 @default.
- W2085778837 hasConcept C42219234 @default.
- W2085778837 hasConcept C519581460 @default.
- W2085778837 hasConcept C541997718 @default.
- W2085778837 hasConcept C55493867 @default.
- W2085778837 hasConcept C71924100 @default.
- W2085778837 hasConcept C98274493 @default.
- W2085778837 hasConceptScore W2085778837C126322002 @default.
- W2085778837 hasConceptScore W2085778837C134018914 @default.
- W2085778837 hasConceptScore W2085778837C181199279 @default.
- W2085778837 hasConceptScore W2085778837C185592680 @default.
- W2085778837 hasConceptScore W2085778837C2775838275 @default.
- W2085778837 hasConceptScore W2085778837C2776109719 @default.
- W2085778837 hasConceptScore W2085778837C2776151105 @default.
- W2085778837 hasConceptScore W2085778837C2778401633 @default.
- W2085778837 hasConceptScore W2085778837C2779306644 @default.
- W2085778837 hasConceptScore W2085778837C2779872217 @default.
- W2085778837 hasConceptScore W2085778837C42219234 @default.
- W2085778837 hasConceptScore W2085778837C519581460 @default.
- W2085778837 hasConceptScore W2085778837C541997718 @default.
- W2085778837 hasConceptScore W2085778837C55493867 @default.
- W2085778837 hasConceptScore W2085778837C71924100 @default.
- W2085778837 hasConceptScore W2085778837C98274493 @default.
- W2085778837 hasIssue "2" @default.
- W2085778837 hasLocation W20857788371 @default.
- W2085778837 hasLocation W20857788372 @default.
- W2085778837 hasOpenAccess W2085778837 @default.
- W2085778837 hasPrimaryLocation W20857788371 @default.
- W2085778837 hasRelatedWork W1990447376 @default.
- W2085778837 hasRelatedWork W1996676577 @default.
- W2085778837 hasRelatedWork W2041257525 @default.
- W2085778837 hasRelatedWork W2102284920 @default.
- W2085778837 hasRelatedWork W2113905390 @default.
- W2085778837 hasRelatedWork W2144173589 @default.
- W2085778837 hasRelatedWork W2314005993 @default.
- W2085778837 hasRelatedWork W2748952813 @default.
- W2085778837 hasRelatedWork W4281566553 @default.
- W2085778837 hasRelatedWork W4303437387 @default.
- W2085778837 hasVolume "23" @default.
- W2085778837 isParatext "false" @default.
- W2085778837 isRetracted "false" @default.
- W2085778837 magId "2085778837" @default.