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- W2085784674 abstract "Appropriately immunized mice display a response that is biologically equivalent to rat rapid expulsion. Only two inbred strains (NFRN and NFSN derived from NIH Swiss mice) have been shown to respond in this manner. Mice of the Balbc, CBA, AHe, C3H, SJL, or C57Bl strains are “nonresponders” which require approximately twice as much intestinal exposure (in days) to Trichinella spiralis to elicit a response half as effective. Genetically, the responder is dominant, autosomal, and does not appear to be linked to the MHC. The characteristics of mouse and rat rapid expulsion of T. spiralis are not identical but share these features: initial rejection within 24 hr of challenge; a rejection efficiency >90%, from 1 to 5 weeks after the primary; induction of response does not require exposure to the complete infection; rapid expulsion is immunologically specific for preadults; adult worms are resistant. While a genetic basis for responsiveness exists in mice there is, as yet, no evidence for genetic control in rats. In both mice and rats, rapid expulsion is distinguished from the intestinal hyperreactivity associated with rejection of the primary infection by the kinetics and amplitude of the rejection of transplanted adult worms." @default.
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- W2085784674 date "1982-06-01" @default.
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- W2085784674 title "Trichinella spiralis: Characterization and strain distribution of rapid expulsion in inbred mice" @default.
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- W2085784674 doi "https://doi.org/10.1016/0014-4894(82)90073-x" @default.
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