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- W2085790472 abstract "In vitro effects of CCA, an anti-arthritis agent, were studied upon autologous mixed lymphocyte reaction (AMLR), lymphocyte mitogenesis, IL 1 and IL 2 production, immunoglobulin production and gamma-interferon (IFN) production. CCA at 50 micrograms/ml, which was not toxic to cells, blocked AMLR, IL 1 production and immunoglobulin production (IgM and IgG) significantly, while CCA at the same dose did not affect IL 2 production and lymphocyte mitogenic responses to Staphylococcus aureus Cowan I(SAC) and pokeweed mitogen(PWM). CCA at both 20 ng/ml and 20 micrograms/ml induced human gamma/IFN. Addition of IL 1 and/or IL 2 reversed inhibitory effect of CCA on AMLR. These data suggest that CCA exerts its actions by mainly affecting T cells and monocytes and can be used as an immunomodulator." @default.
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- W2085790472 date "1986-01-01" @default.
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- W2085790472 title "Immunopharmacological study of CCA(Lobenzarit disodium), an anti-arthritis agent — I. Abrogation of IL 1 secretion by LPS-stimulated human monocytes and induction of γ-interferon production with CCA" @default.
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- W2085790472 doi "https://doi.org/10.1016/0192-0561(86)90114-1" @default.
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