FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085804523> ?p ?o ?g. }

• W2085804523 endingPage "1004" @default.
• W2085804523 startingPage "999" @default.
• W2085804523 abstract "Small matrices of calcium alginate or aluminium alginate have been investigated as possible controlled release systems for drugs. The objective of the present study was to sustain the release of theophylline from alginate matrices using different concentrations of aluminium chloride and calcium chloride in presence and absence of HPMC. Tablets containing differing concentrations of aluminium and calcium chloride were produced and the release rate of theophylline was tested using the basket dissolution apparatus over 8 h. Increasing amounts of aluminium chloride from 0.0001 to 0.00068 moles decreased the release of theophylline from 95.1 +/- 0.27 to 29.5 +/- 1.5, indicating a significant effect of aluminium ions on a reduction in the release rate of theophylline from sodium alginate matrices. In the case of matrices containing different concentrations of calcium ions, as the concentration of calcium chloride increased, the release rate increased to an optimum then declined after this. This was due to insufficient calcium ions being available to cross-link with the sodium alginate to form an insoluble gel. The effect of aluminium ions, as this is a trivalent ion compared to calcium, which is a divalent ion, aluminium ions are able to decrease the release rate with a smaller concentration compared to calcium ions. The results also showed that the presence of HPMC caused a reduction in release rate of theophylline from alginate matrices containing calcium chloride. Whereas, in the case of alginate matrices containing aluminium chloride the release rate of theophylline increased in presence of HPMC. For comparing the dissolution data, dissolution efficiency (DE) was used. The values of DE are consistent with the dissolution data. The results show that within a formulation series, DE values generally decrease when the cation concentration increases and this criterion can be used to describe the effect of calcium and aluminium ions on the release behaviour of theophylline from polymeric matrices." @default.
• W2085804523 created "2016-06-24" @default.
• W2085804523 creator A5023571572 @default.
• W2085804523 creator A5077542770 @default.
• W2085804523 date "2004-12-01" @default.
• W2085804523 modified "2023-10-04" @default.
• W2085804523 title "In situ cross-linking of sodium alginate with calcium and aluminum ions to sustain the release of theophylline from polymeric matrices" @default.
• W2085804523 cites W110719922 @default.
• W2085804523 cites W1586799259 @default.
• W2085804523 cites W1995040912 @default.
• W2085804523 cites W2012615336 @default.
• W2085804523 cites W2035755109 @default.
• W2085804523 cites W2047169908 @default.
• W2085804523 cites W2056174843 @default.
• W2085804523 cites W2062270991 @default.
• W2085804523 cites W2064016073 @default.
• W2085804523 cites W2081625070 @default.
• W2085804523 cites W2083379076 @default.
• W2085804523 cites W2085828332 @default.
• W2085804523 cites W4241715686 @default.
• W2085804523 cites W2023585844 @default.
• W2085804523 doi "https://doi.org/10.1016/j.farmac.2004.08.006" @default.
• W2085804523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15598436" @default.
• W2085804523 hasPublicationYear "2004" @default.
• W2085804523 type Work @default.
• W2085804523 sameAs 2085804523 @default.
• W2085804523 citedByCount "88" @default.
• W2085804523 countsByYear W20858045232012 @default.
• W2085804523 countsByYear W20858045232013 @default.
• W2085804523 countsByYear W20858045232014 @default.
• W2085804523 countsByYear W20858045232015 @default.
• W2085804523 countsByYear W20858045232016 @default.
• W2085804523 countsByYear W20858045232017 @default.
• W2085804523 countsByYear W20858045232018 @default.
• W2085804523 countsByYear W20858045232019 @default.
• W2085804523 countsByYear W20858045232020 @default.
• W2085804523 countsByYear W20858045232021 @default.
• W2085804523 countsByYear W20858045232022 @default.
• W2085804523 countsByYear W20858045232023 @default.
• W2085804523 crossrefType "journal-article" @default.
• W2085804523 hasAuthorship W2085804523A5023571572 @default.
• W2085804523 hasAuthorship W2085804523A5077542770 @default.
• W2085804523 hasConcept C134018914 @default.
• W2085804523 hasConcept C13965031 @default.
• W2085804523 hasConcept C178790620 @default.
• W2085804523 hasConcept C179104552 @default.
• W2085804523 hasConcept C185592680 @default.
• W2085804523 hasConcept C2777317207 @default.
• W2085804523 hasConcept C2778095195 @default.
• W2085804523 hasConcept C2778695967 @default.
• W2085804523 hasConcept C2778713300 @default.
• W2085804523 hasConcept C513153333 @default.
• W2085804523 hasConcept C519063684 @default.
• W2085804523 hasConcept C537181965 @default.
• W2085804523 hasConcept C71924100 @default.
• W2085804523 hasConcept C88380143 @default.
• W2085804523 hasConceptScore W2085804523C134018914 @default.
• W2085804523 hasConceptScore W2085804523C13965031 @default.
• W2085804523 hasConceptScore W2085804523C178790620 @default.
• W2085804523 hasConceptScore W2085804523C179104552 @default.
• W2085804523 hasConceptScore W2085804523C185592680 @default.
• W2085804523 hasConceptScore W2085804523C2777317207 @default.
• W2085804523 hasConceptScore W2085804523C2778095195 @default.
• W2085804523 hasConceptScore W2085804523C2778695967 @default.
• W2085804523 hasConceptScore W2085804523C2778713300 @default.
• W2085804523 hasConceptScore W2085804523C513153333 @default.
• W2085804523 hasConceptScore W2085804523C519063684 @default.
• W2085804523 hasConceptScore W2085804523C537181965 @default.
• W2085804523 hasConceptScore W2085804523C71924100 @default.
• W2085804523 hasConceptScore W2085804523C88380143 @default.
• W2085804523 hasIssue "12" @default.
• W2085804523 hasLocation W20858045231 @default.
• W2085804523 hasLocation W20858045232 @default.
• W2085804523 hasOpenAccess W2085804523 @default.
• W2085804523 hasPrimaryLocation W20858045231 @default.
• W2085804523 hasRelatedWork W1981842419 @default.
• W2085804523 hasRelatedWork W2000241480 @default.
• W2085804523 hasRelatedWork W2036261257 @default.
• W2085804523 hasRelatedWork W2050815522 @default.
• W2085804523 hasRelatedWork W2051383802 @default.
• W2085804523 hasRelatedWork W2059343233 @default.
• W2085804523 hasRelatedWork W2085804523 @default.
• W2085804523 hasRelatedWork W2953123219 @default.
• W2085804523 hasRelatedWork W4206096725 @default.
• W2085804523 hasRelatedWork W2461197035 @default.
• W2085804523 hasVolume "59" @default.
• W2085804523 isParatext "false" @default.
• W2085804523 isRetracted "false" @default.
• W2085804523 magId "2085804523" @default.
• W2085804523 workType "article" @default.