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• W2085805230 endingPage "1984" @default.
• W2085805230 startingPage "1973" @default.
• W2085805230 abstract "Background: Many organisms undergo closed mitosis and locate tubulin and mitotic kinases to nuclei only during mitosis. How this is regulated is unknown. Interestingly, the NIMA kinase of Aspergillus nidulans interacts with two nuclear pore complex (NPC) proteins and NIMA is required for mitotic localization of the Cdk1 kinase to nuclei. Therefore, we wished to define the mechanism by which the NPC is regulated during A. nidulans' closed mitosis.Results: The structural makeup of the NPC is dramatically changed during A. nidulans' mitosis. At least five NPC proteins disperse throughout the cell during mitosis while at least three structural components remain at the NPC. These modifications correlate with marked changes in the function of the NPC. Notably, during mitosis, An-RanGAP is not excluded from nuclei, and five other nuclear or cytoplasmic proteins investigated fail to locate as they do during interphase. Mitotic modification of the NPC requires NIMA and Cdk1 kinase activation. NIMA appears to be particularly important. Most strikingly, ectopic induction of NIMA promotes mitotic-like changes in NPC structure and function during S phase. Furthermore, NIMA locates to the NPC during entry into mitosis, and a dominant-negative version of NIMA that causes G2 delay dwells at the NPC.Conclusions: We conclude that partial NPC disassembly under control of NIMA and Cdk1 in A. nidulans may represent a new mechanism for regulating closed mitoses. We hypothesize that proteins locate by their relative binding affinities within the cell during A. nidulans' closed mitosis, analogous to what occurs during open mitosis." @default.
• W2085805230 created "2016-06-24" @default.
• W2085805230 creator A5021171945 @default.
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• W2085805230 date "2004-11-01" @default.
• W2085805230 modified "2023-10-18" @default.
• W2085805230 title "Partial Nuclear Pore Complex Disassembly during Closed Mitosis in Aspergillus nidulans" @default.
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• W2085805230 cites W1755013959 @default.
• W2085805230 cites W1766728438 @default.
• W2085805230 cites W1868422248 @default.
• W2085805230 cites W1898015186 @default.
• W2085805230 cites W1928797097 @default.
• W2085805230 cites W1953353981 @default.
• W2085805230 cites W1965895754 @default.
• W2085805230 cites W1966205440 @default.
• W2085805230 cites W1966219754 @default.
• W2085805230 cites W1978450158 @default.
• W2085805230 cites W1978798894 @default.
• W2085805230 cites W1982413468 @default.
• W2085805230 cites W1983501540 @default.
• W2085805230 cites W1983575076 @default.
• W2085805230 cites W1986148855 @default.
• W2085805230 cites W1994512535 @default.
• W2085805230 cites W1996364283 @default.
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• W2085805230 cites W2004447793 @default.
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• W2085805230 cites W2011052397 @default.
• W2085805230 cites W2015557154 @default.
• W2085805230 cites W2022546848 @default.
• W2085805230 cites W2025592839 @default.
• W2085805230 cites W2039933839 @default.
• W2085805230 cites W2040321397 @default.
• W2085805230 cites W2045509241 @default.
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• W2085805230 cites W2076241227 @default.
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• W2085805230 cites W2118326823 @default.
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• W2085805230 doi "https://doi.org/10.1016/j.cub.2004.10.050" @default.
• W2085805230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15556859" @default.
• W2085805230 hasPublicationYear "2004" @default.
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