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- W2085809715 abstract "As part of a TSCA Section 4 Consent Order agreement, the biodegradation of the organosilicone octamethylcyclotetrasiloxane (OMCTS) was investigated using an updated version of the Bourquin Eco-Core design. This study illustrates the concept that caution must be exercised in all data interpretation but especially when nonstandardized studies are used in the regulatory decision-making process. Because of OMCTS' unique combination of high volatility and low water solubility, modifications to the test procedures were necessary, as were a series of supplemental studies conducted to aid in the interpretation of the original study results. While the correct interpretation of the data was achieved, the use of supplemental studies highlights the importance of professional judgment in conducting testing for regulatory purposes. Researchers should not hesitate to question the appropriateness of standard and nonstandard study designs as related to the specific physicochemical properties of the test material being investigated (e.g., Henry's Law constant). In addition, investigators should be prepared to conduct supplemental studies and analyses as needed to ensure the accurate interpretation of study results. Misinterpretation of data can have serious ramifications in a regulatory context, whether it may result in keeping an environmentally sound product off the market, in misdirection of limited financial and personnel resources away from more serious environmental concerns, or in placing unwarranted limitations on a given chemical or chemical product. © 1996 by John Wiley & Sons, Inc." @default.
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- W2085809715 date "1996-01-01" @default.
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- W2085809715 title "Interpretation of data from nonstandard studies: The fate of octamethylcyclotetrasiloxane in a sediment/water microcosm system" @default.
- W2085809715 doi "https://doi.org/10.1002/(sici)1098-2256(1996)11:2<145::aid-tox10>3.0.co;2-c" @default.
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