Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085811290> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2085811290 endingPage "3107" @default.
- W2085811290 startingPage "3099" @default.
- W2085811290 abstract "The air–water surface tension kinetic and steady state behavior exhibited by a recombinant Factor VIII were recorded in the presence of the surfactant Tween 80. The rate of surface tension decrease was determined to be greater for rFVIII–Tween mixtures than for Tween acting alone, at all Tween concentrations studied (8–108 ppm). In addition, steady state interfacial behavior was determined to be governed entirely by surfactant adsorption in mixtures with Tween concentrations greater than or equal to about 18 ppm. The formation of aggregates, tertiary structure change, and biological activity of rFVIII in agitated as well as unagitated samples were monitored using turbidity measurements, intrinsic fluorescence spectroscopy, and the activated partial thromboplastin time, respectively. The results are consistent with two mechanisms characterizing the surfactant-mediated stabilization of rFVIII: the rapid, preferential adsorption of Tween molecules relative to rFVIII molecules at the air–water interface, and Tween association with rFVIII in solution to provide a steric barrier to aggregation. While both mechanisms are relevant in the presence of an interface, evidence recorded here suggests that the preferential adsorption of Tween at the interface is the major stabilization mechanism while the effectiveness of Tween association with rFVIII is compromised in agitated samples. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3099–3107, 2009" @default.
- W2085811290 created "2016-06-24" @default.
- W2085811290 creator A5013737099 @default.
- W2085811290 creator A5014971746 @default.
- W2085811290 creator A5024284243 @default.
- W2085811290 creator A5058173746 @default.
- W2085811290 date "2009-09-01" @default.
- W2085811290 modified "2023-10-15" @default.
- W2085811290 title "Adsorption and function of recombinant Factor VIII at the air–water interface in the presence of Tween 80" @default.
- W2085811290 cites W13502199 @default.
- W2085811290 cites W1967949780 @default.
- W2085811290 cites W1986397390 @default.
- W2085811290 cites W1992806114 @default.
- W2085811290 cites W1998029389 @default.
- W2085811290 cites W2020614077 @default.
- W2085811290 cites W2021283345 @default.
- W2085811290 cites W2022927681 @default.
- W2085811290 cites W2066775733 @default.
- W2085811290 cites W2082877775 @default.
- W2085811290 cites W2095049818 @default.
- W2085811290 cites W2097188750 @default.
- W2085811290 cites W2136842724 @default.
- W2085811290 cites W2156682306 @default.
- W2085811290 cites W3023309306 @default.
- W2085811290 cites W66465450 @default.
- W2085811290 doi "https://doi.org/10.1002/jps.21569" @default.
- W2085811290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18781611" @default.
- W2085811290 hasPublicationYear "2009" @default.
- W2085811290 type Work @default.
- W2085811290 sameAs 2085811290 @default.
- W2085811290 citedByCount "40" @default.
- W2085811290 countsByYear W20858112902012 @default.
- W2085811290 countsByYear W20858112902013 @default.
- W2085811290 countsByYear W20858112902014 @default.
- W2085811290 countsByYear W20858112902015 @default.
- W2085811290 countsByYear W20858112902016 @default.
- W2085811290 countsByYear W20858112902017 @default.
- W2085811290 countsByYear W20858112902018 @default.
- W2085811290 countsByYear W20858112902019 @default.
- W2085811290 countsByYear W20858112902020 @default.
- W2085811290 countsByYear W20858112902021 @default.
- W2085811290 countsByYear W20858112902022 @default.
- W2085811290 countsByYear W20858112902023 @default.
- W2085811290 crossrefType "journal-article" @default.
- W2085811290 hasAuthorship W2085811290A5013737099 @default.
- W2085811290 hasAuthorship W2085811290A5014971746 @default.
- W2085811290 hasAuthorship W2085811290A5024284243 @default.
- W2085811290 hasAuthorship W2085811290A5058173746 @default.
- W2085811290 hasConcept C121332964 @default.
- W2085811290 hasConcept C150394285 @default.
- W2085811290 hasConcept C178790620 @default.
- W2085811290 hasConcept C185592680 @default.
- W2085811290 hasConcept C201194858 @default.
- W2085811290 hasConcept C32909587 @default.
- W2085811290 hasConcept C43617362 @default.
- W2085811290 hasConcept C55493867 @default.
- W2085811290 hasConcept C58226133 @default.
- W2085811290 hasConcept C71240020 @default.
- W2085811290 hasConcept C78772589 @default.
- W2085811290 hasConcept C8892853 @default.
- W2085811290 hasConcept C97355855 @default.
- W2085811290 hasConceptScore W2085811290C121332964 @default.
- W2085811290 hasConceptScore W2085811290C150394285 @default.
- W2085811290 hasConceptScore W2085811290C178790620 @default.
- W2085811290 hasConceptScore W2085811290C185592680 @default.
- W2085811290 hasConceptScore W2085811290C201194858 @default.
- W2085811290 hasConceptScore W2085811290C32909587 @default.
- W2085811290 hasConceptScore W2085811290C43617362 @default.
- W2085811290 hasConceptScore W2085811290C55493867 @default.
- W2085811290 hasConceptScore W2085811290C58226133 @default.
- W2085811290 hasConceptScore W2085811290C71240020 @default.
- W2085811290 hasConceptScore W2085811290C78772589 @default.
- W2085811290 hasConceptScore W2085811290C8892853 @default.
- W2085811290 hasConceptScore W2085811290C97355855 @default.
- W2085811290 hasIssue "9" @default.
- W2085811290 hasLocation W20858112901 @default.
- W2085811290 hasLocation W20858112902 @default.
- W2085811290 hasOpenAccess W2085811290 @default.
- W2085811290 hasPrimaryLocation W20858112901 @default.
- W2085811290 hasRelatedWork W1518596711 @default.
- W2085811290 hasRelatedWork W2075681821 @default.
- W2085811290 hasRelatedWork W2082986751 @default.
- W2085811290 hasRelatedWork W2086322789 @default.
- W2085811290 hasRelatedWork W2089151306 @default.
- W2085811290 hasRelatedWork W2186397988 @default.
- W2085811290 hasRelatedWork W2356640391 @default.
- W2085811290 hasRelatedWork W2595024643 @default.
- W2085811290 hasRelatedWork W3134856963 @default.
- W2085811290 hasRelatedWork W3155628416 @default.
- W2085811290 hasVolume "98" @default.
- W2085811290 isParatext "false" @default.
- W2085811290 isRetracted "false" @default.
- W2085811290 magId "2085811290" @default.
- W2085811290 workType "article" @default.