FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085816375> ?p ?o ?g. }

• W2085816375 endingPage "75" @default.
• W2085816375 startingPage "69" @default.
• W2085816375 abstract "Experimental findings support clinical evidence that brain death impairs the viability of organs for transplantation, triggering hemodynamic, hormonal, and inflammatory responses. However, several of these events could be consequences of brain death-associated trauma. This study investigated microcirculatory alterations and systemic inflammatory markers in brain-dead rats and the influence of the associated trauma.Brain death was induced using intracranial balloon inflation; sham-operated rats were trepanned only. After 30 or 180 min, the mesenteric microcirculation was observed using intravital microscopy. The expression of Pselectin and ICAM-1 on the endothelium was evaluated using immunohistochemistry. The serum cytokine, chemokine, and corticosterone levels were quantified using enzyme-linked immunosorbent assays. White blood cell counts were also determined.Brain death resulted in a decrease in the mesenteric perfusion to 30%, a 2.6-fold increase in the expression of ICAM-1 and leukocyte migration at the mesentery, a 70% reduction in the serum corticosterone level and pronounced leukopenia. Similar increases in the cytokine and chemokine levels were seen in the both the experimental and control animals.The data presented in this study suggest that brain death itself induces hypoperfusion in the mesenteric microcirculation that is associated with a pronounced reduction in the endogenous corticosterone level, thereby leading to increased local inflammation and organ dysfunction. These events are paradoxically associated with induced leukopenia after brain damage." @default.
• W2085816375 created "2016-06-24" @default.
• W2085816375 creator A5011565258 @default.
• W2085816375 creator A5015456024 @default.
• W2085816375 creator A5026487818 @default.
• W2085816375 creator A5048377535 @default.
• W2085816375 creator A5050727424 @default.
• W2085816375 creator A5057760165 @default.
• W2085816375 creator A5070282848 @default.
• W2085816375 creator A5091741428 @default.
• W2085816375 creator A5091833826 @default.
• W2085816375 date "2012-01-01" @default.
• W2085816375 modified "2023-09-27" @default.
• W2085816375 title "Paradoxical effects of brain death and associated trauma on rat mesenteric microcirculation: an intravital microscopic study" @default.
• W2085816375 cites W145671396 @default.
• W2085816375 cites W1490292682 @default.
• W2085816375 cites W1600560134 @default.
• W2085816375 cites W186752733 @default.
• W2085816375 cites W1908908549 @default.
• W2085816375 cites W1947009034 @default.
• W2085816375 cites W1964672803 @default.
• W2085816375 cites W1974262270 @default.
• W2085816375 cites W1990823740 @default.
• W2085816375 cites W2012142351 @default.
• W2085816375 cites W2018114852 @default.
• W2085816375 cites W2032371793 @default.
• W2085816375 cites W2035809865 @default.
• W2085816375 cites W2035973753 @default.
• W2085816375 cites W2039526241 @default.
• W2085816375 cites W2039558665 @default.
• W2085816375 cites W2045806619 @default.
• W2085816375 cites W2056152745 @default.
• W2085816375 cites W2062465538 @default.
• W2085816375 cites W2088686943 @default.
• W2085816375 cites W2096314358 @default.
• W2085816375 cites W2096875128 @default.
• W2085816375 cites W2101151014 @default.
• W2085816375 cites W2107748719 @default.
• W2085816375 cites W2109699460 @default.
• W2085816375 cites W2119573232 @default.
• W2085816375 cites W2130861603 @default.
• W2085816375 cites W2139319526 @default.
• W2085816375 cites W2139644186 @default.
• W2085816375 cites W2156751422 @default.
• W2085816375 cites W2166914728 @default.
• W2085816375 cites W4313347712 @default.
• W2085816375 doi "https://doi.org/10.6061/clinics/2012(01)11" @default.
• W2085816375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248604" @default.
• W2085816375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22249483" @default.
• W2085816375 hasPublicationYear "2012" @default.
• W2085816375 type Work @default.
• W2085816375 sameAs 2085816375 @default.
• W2085816375 citedByCount "22" @default.
• W2085816375 countsByYear W20858163752012 @default.
• W2085816375 countsByYear W20858163752013 @default.
• W2085816375 countsByYear W20858163752015 @default.
• W2085816375 countsByYear W20858163752016 @default.
• W2085816375 countsByYear W20858163752017 @default.
• W2085816375 countsByYear W20858163752018 @default.
• W2085816375 countsByYear W20858163752019 @default.
• W2085816375 countsByYear W20858163752020 @default.
• W2085816375 countsByYear W20858163752023 @default.
• W2085816375 crossrefType "journal-article" @default.
• W2085816375 hasAuthorship W2085816375A5011565258 @default.
• W2085816375 hasAuthorship W2085816375A5015456024 @default.
• W2085816375 hasAuthorship W2085816375A5026487818 @default.
• W2085816375 hasAuthorship W2085816375A5048377535 @default.
• W2085816375 hasAuthorship W2085816375A5050727424 @default.
• W2085816375 hasAuthorship W2085816375A5057760165 @default.
• W2085816375 hasAuthorship W2085816375A5070282848 @default.
• W2085816375 hasAuthorship W2085816375A5091741428 @default.
• W2085816375 hasAuthorship W2085816375A5091833826 @default.
• W2085816375 hasBestOaLocation W20858163751 @default.
• W2085816375 hasConcept C126322002 @default.
• W2085816375 hasConcept C12722491 @default.
• W2085816375 hasConcept C134018914 @default.
• W2085816375 hasConcept C142724271 @default.
• W2085816375 hasConcept C2859252 @default.
• W2085816375 hasConcept C71924100 @default.
• W2085816375 hasConceptScore W2085816375C126322002 @default.
• W2085816375 hasConceptScore W2085816375C12722491 @default.
• W2085816375 hasConceptScore W2085816375C134018914 @default.
• W2085816375 hasConceptScore W2085816375C142724271 @default.
• W2085816375 hasConceptScore W2085816375C2859252 @default.
• W2085816375 hasConceptScore W2085816375C71924100 @default.
• W2085816375 hasIssue "1" @default.
• W2085816375 hasLocation W20858163751 @default.
• W2085816375 hasLocation W20858163752 @default.
• W2085816375 hasLocation W20858163753 @default.
• W2085816375 hasLocation W20858163754 @default.
• W2085816375 hasLocation W20858163755 @default.
• W2085816375 hasLocation W20858163756 @default.
• W2085816375 hasOpenAccess W2085816375 @default.
• W2085816375 hasPrimaryLocation W20858163751 @default.
• W2085816375 hasRelatedWork W1963700430 @default.
• W2085816375 hasRelatedWork W1966504330 @default.
• W2085816375 hasRelatedWork W1966775726 @default.
• W2085816375 hasRelatedWork W1979139803 @default.

• next