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• W2085819162 endingPage "77" @default.
• W2085819162 startingPage "72" @default.
• W2085819162 abstract "Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K+ channel and Ca2 + channel blocker effects on QT interval. However, there is no report showing that this technique can be used to predict multichannel blocker potential for QT prolongation. The aim of this study is to show that FPD from MEA (Multielectrode array) of hiPS-CMs can detect QT prolongation induced by multichannel blockers. hiPS-CMs were seeded onto MEA and FPD was measured for 2 min every 10 min for 30 min after drug exposure for the vehicle and each drug concentration. IKr and IKs blockers concentration-dependently prolonged corrected FPD (FPDc), whereas Ca2 + channel blockers concentration-dependently shortened FPDc. Also, the multichannel blockers Amiodarone, Paroxetine, Terfenadine and Citalopram prolonged FPDc in a concentration dependent manner. Finally, the IKr blockers, Terfenadine and Citalopram, which are reported to cause Torsade de Pointes (TdP) in clinical practice, produced early afterdepolarization (EAD). hiPS-CMs using MEA system and FPDc can predict the effects of drug candidates on QT interval. This study also shows that this assay can help detect EAD for drugs with TdP potential." @default.
• W2085819162 created "2016-06-24" @default.
• W2085819162 creator A5002052643 @default.
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• W2085819162 date "2014-07-01" @default.
• W2085819162 modified "2023-09-27" @default.
• W2085819162 title "Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation" @default.
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• W2085819162 doi "https://doi.org/10.1016/j.taap.2014.04.007" @default.
• W2085819162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24742750" @default.
• W2085819162 hasPublicationYear "2014" @default.
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