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• W2085832032 abstract "A prospective screening of 473 hospitalized HIV infected patients gave 253 bacterial infections in 169 patients. Pneumonia was the most frequent infection (n=106). Infections were documented in 111/253 (44%) episodes. The most frequent isolated pathogens were Staphylococcus sp. (n=25), Pseudomonas aeruginosa (n=21), Escherichia coli (n=20), and Streptococcus pneumoniae (n=18). Factors associated with infections were: intravenous drug use (RR: 1.38; 95% CI: 1.07–1.77, p<0.004), CD4<100 (RR: 1.39; 95% CI: 1.09–1.64, p<0.007), and previous AIDS (RR: 1.43; 95% CI: 1.1–1.867, p<0.002). However, IV drug use (RR 1.8; 95% CI 1.31–2.46, p<10−3) was the only significant factor for community acquired infections while CD4<100 (RR 4.54; 95% CI: 1.86–11.07, p<10−3) and AIDS (RR 4.71, 95% CI 2.05–10.85, p<10−4) were significant only for nosocomial infections. We conclude that the main risk factors for community acquired and nosocomial infections are intravenous drug use and AIDS, respectively. Les infections bactériennes ont été évaluées prospectivement chez 473 patients hospitalisés infectés par le VIH dont 169 ont présenté 253 infections. Le site pulmonaire était le plus souvent en cause (n=106). Une documentation bactériologique a été obtenue dans 111/253 (44%) épisodes. Les pathogènes le plus souvent isolés étaient: Staphylococcus sp. (n=25), Pseudomonas aeruginosa (n=21), Escherichia coli (n=20) et Streptococcus pneumoniae (n=18). Les facteurs associés à la présence d'une infection bactérienne étaient: la toxicomanie intraveineuse (RR: 1,38; IC95: 1,07–1,77, p<0.004), des CD4<100 (RR: 1,39; IC95: 1,09–1,64, p<0.007), et un SIDA (RR: 1,43; IC95: 1,1–1,86, p<0.002). La toxicomanie intraveineuse était le seul facteur restant significatif pour les infections communautaires (RR 1,8; IC95: 1,31–2,46, p<10−3) alors que le taux de CD4 (RR 4,54; IC95: 1,86–11,07, p<10−3) et le stade SIDA (RR 4,71 IC95: 2,05–10,85, p<10−4) n'étaient significatifs que pour les infections nosocomiales. La toxicomanie intraveineuse est ainsi le principal facteur de risque d'infection bactérienne communautaire et le SIDA le principal facteur de risque d'infection nosocomiale." @default.
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• W2085832032 date "1998-12-01" @default.
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• W2085832032 title "Bacterial infections in hospitalized HIV patients" @default.
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• W2085832032 doi "https://doi.org/10.1016/s0399-077x(98)80137-6" @default.
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