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- W2085832652 abstract "The effect of kainic acid on the action of l-glutamate on the crayfish muscle was investigated. l-Glutamate was applied iontophoretically and potential changes were recorded intracellularly. Kainic acid was then added to the bath solution. When the peak time of the glutamate potential was less than about 50–100 msec, kainic acid (10−4 M) had little or no effect on the amplitude. However, when the peak time of the glutamate potential was about 800 msec, kainic acid increased the amplitude of the glutamate potential to three times that of the control. The glutamate potential was, in many cases, prolonged by the action of kainic acid. When the amplitude distribution of the glutamate potential was measured by injecting the same doses of l-glutamate along a muscle fibre, the area sensitive to l-glutamate was larger in kainic acid solution than in the normal solution. It is suggested that sensitivity of the junctional receptor is not changed by the action of kainic acid, but the extra-junctional receptor, which is not responsive to l-glutamate in the normal solution becomes sensitive to l-glutamate by kainic acid." @default.
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- W2085832652 date "1975-09-01" @default.
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- W2085832652 title "Effects of kainic acid on the glutamate receptors of the crayfish muscle" @default.
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- W2085832652 doi "https://doi.org/10.1016/0028-3908(75)90084-2" @default.
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