Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085834766> ?p ?o ?g. }
- W2085834766 endingPage "2513" @default.
- W2085834766 startingPage "2506" @default.
- W2085834766 abstract "Amino-acid transporters are necessary for the tumour cell growth and survival, and have a crucial role in the development and invasiveness of cancer cells. But, it remains unclear about the prognostic significance of L-type amino-acid transporter 1 (LAT1), system ASC amino-acid transporter-2 (ASCT2), and xCT expression in patients with tongue cancer. We conducted the clinicopathological study to investigate the protein expression of these amino-acid transporters in tongue cancer. Eighty-five patients with surgically resected tongue cancer were evaluated. Tumour sections were stained by immunohistochemistry for LAT1, ASCT2, xCT, 4F2hc/CD98hc (4F2hc), Ki-67, and microvessel density (MVD) determined by CD34, and p53. L-type amino-acid transporter 1 and 4F2hc were highly expressed in 61% (52 out of 85) and 45% (38 out of 47), respectively. ASC amino-acid transporter-2 and xCT were positively expressed in 59% (50 out of 85) and 21% (18 out of 85), respectively. The expression of both LAT1 and ASCT2 was significantly associated with disease staging, lymph-node metastasis, lymphatic permeation, 4F2hc expression and cell proliferation (Ki-67). xCT expression indicated a significant association with advanced stage and tumour factor. By univariate analysis, disease staging, lymphatic permeation, vascular invasion, LAT1, ASCT2, 4F2hc, and Ki-67 had a significant relationship with overall survival. Multivariate analysis confirmed that LAT1 was an independent prognostic factor for predicting poor prognosis. L-type amino-acid transporter 1 and ASCT2 can serve as a significant prognostic factor for predicting worse outcome after surgical treatment and may have an important role in the development and aggressiveness of tongue cancer." @default.
- W2085834766 created "2016-06-24" @default.
- W2085834766 creator A5010669068 @default.
- W2085834766 creator A5033780369 @default.
- W2085834766 creator A5034452868 @default.
- W2085834766 creator A5038459682 @default.
- W2085834766 creator A5053649418 @default.
- W2085834766 creator A5056081259 @default.
- W2085834766 creator A5058040672 @default.
- W2085834766 creator A5060671990 @default.
- W2085834766 creator A5067763773 @default.
- W2085834766 creator A5069726026 @default.
- W2085834766 creator A5070444294 @default.
- W2085834766 creator A5074929594 @default.
- W2085834766 creator A5082494272 @default.
- W2085834766 creator A5085034288 @default.
- W2085834766 date "2014-04-24" @default.
- W2085834766 modified "2023-10-12" @default.
- W2085834766 title "Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer" @default.
- W2085834766 cites W1956844386 @default.
- W2085834766 cites W1986079728 @default.
- W2085834766 cites W1991054305 @default.
- W2085834766 cites W2000884856 @default.
- W2085834766 cites W2020196369 @default.
- W2085834766 cites W2025721262 @default.
- W2085834766 cites W2029866449 @default.
- W2085834766 cites W2040329518 @default.
- W2085834766 cites W2069057214 @default.
- W2085834766 cites W2079212747 @default.
- W2085834766 cites W2080675548 @default.
- W2085834766 cites W2082094878 @default.
- W2085834766 cites W2084106537 @default.
- W2085834766 cites W2084214117 @default.
- W2085834766 cites W2090511366 @default.
- W2085834766 cites W2102117986 @default.
- W2085834766 cites W2128931982 @default.
- W2085834766 cites W2139405623 @default.
- W2085834766 cites W2147896673 @default.
- W2085834766 cites W2157182807 @default.
- W2085834766 cites W2160500503 @default.
- W2085834766 cites W2162420845 @default.
- W2085834766 cites W2164509931 @default.
- W2085834766 cites W2169903226 @default.
- W2085834766 doi "https://doi.org/10.1038/bjc.2014.178" @default.
- W2085834766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4021522" @default.
- W2085834766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24762957" @default.
- W2085834766 hasPublicationYear "2014" @default.
- W2085834766 type Work @default.
- W2085834766 sameAs 2085834766 @default.
- W2085834766 citedByCount "99" @default.
- W2085834766 countsByYear W20858347662014 @default.
- W2085834766 countsByYear W20858347662015 @default.
- W2085834766 countsByYear W20858347662016 @default.
- W2085834766 countsByYear W20858347662017 @default.
- W2085834766 countsByYear W20858347662018 @default.
- W2085834766 countsByYear W20858347662019 @default.
- W2085834766 countsByYear W20858347662020 @default.
- W2085834766 countsByYear W20858347662021 @default.
- W2085834766 countsByYear W20858347662022 @default.
- W2085834766 countsByYear W20858347662023 @default.
- W2085834766 crossrefType "journal-article" @default.
- W2085834766 hasAuthorship W2085834766A5010669068 @default.
- W2085834766 hasAuthorship W2085834766A5033780369 @default.
- W2085834766 hasAuthorship W2085834766A5034452868 @default.
- W2085834766 hasAuthorship W2085834766A5038459682 @default.
- W2085834766 hasAuthorship W2085834766A5053649418 @default.
- W2085834766 hasAuthorship W2085834766A5056081259 @default.
- W2085834766 hasAuthorship W2085834766A5058040672 @default.
- W2085834766 hasAuthorship W2085834766A5060671990 @default.
- W2085834766 hasAuthorship W2085834766A5067763773 @default.
- W2085834766 hasAuthorship W2085834766A5069726026 @default.
- W2085834766 hasAuthorship W2085834766A5070444294 @default.
- W2085834766 hasAuthorship W2085834766A5074929594 @default.
- W2085834766 hasAuthorship W2085834766A5082494272 @default.
- W2085834766 hasAuthorship W2085834766A5085034288 @default.
- W2085834766 hasBestOaLocation W20858347661 @default.
- W2085834766 hasConcept C104317684 @default.
- W2085834766 hasConcept C121608353 @default.
- W2085834766 hasConcept C126322002 @default.
- W2085834766 hasConcept C142724271 @default.
- W2085834766 hasConcept C143998085 @default.
- W2085834766 hasConcept C149011108 @default.
- W2085834766 hasConcept C181152851 @default.
- W2085834766 hasConcept C204232928 @default.
- W2085834766 hasConcept C2779744641 @default.
- W2085834766 hasConcept C2781313199 @default.
- W2085834766 hasConcept C502942594 @default.
- W2085834766 hasConcept C515207424 @default.
- W2085834766 hasConcept C55493867 @default.
- W2085834766 hasConcept C71924100 @default.
- W2085834766 hasConcept C86803240 @default.
- W2085834766 hasConcept C96232424 @default.
- W2085834766 hasConceptScore W2085834766C104317684 @default.
- W2085834766 hasConceptScore W2085834766C121608353 @default.
- W2085834766 hasConceptScore W2085834766C126322002 @default.
- W2085834766 hasConceptScore W2085834766C142724271 @default.
- W2085834766 hasConceptScore W2085834766C143998085 @default.
- W2085834766 hasConceptScore W2085834766C149011108 @default.