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- W2085836291 abstract "Neonatal impregnation with gonadal steroids permanently affects protein synthesis and enzyme activity in a score of peripheral organs. Many, if not all, of these neonatal effects, however, do not come to expression in the absence of the pituitary or after disruption of the hypothalamo-hypophyseal axis. It may be hypothesized that during the neonatal period of differentiation gonadal hormones permanently change the production or secretion of known or unknown hypophyseal hormones. At this point the question should be asked whether all neonatal effects of gonadal hormones are mediated by the same or by different hypophyseal factors? A survey of the pertinent literature reveals 6 clusters of proteins and enzymes whose concentration or activity in adulthood is jointly, but in a distinct way, regulated by pituitary and gonadal hormones. Proteins belonging to two of these clusters were studied longitudinally by radial immunodiffusion in hypophysectomized rats and in hypophysectomized rats with pituitary implants and this before and after treatment with CB 154. Prolactin seems to be the mediator of the effects of gonadal hormones on serum transcortin levels." @default.
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- W2085836291 date "1977-05-01" @default.
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- W2085836291 title "Role of the hypothalamo-hypophyseal axis in neonatal androgenisation and its postpubertal expression" @default.
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- W2085836291 doi "https://doi.org/10.1016/0022-4731(77)90265-5" @default.
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