FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085839596> ?p ?o ?g. }

• W2085839596 endingPage "262" @default.
• W2085839596 startingPage "256" @default.
• W2085839596 abstract "The effect of prostaglandin E1 (PGE1) on osmotic water flow across toad bladder and cyclic AMP content of the mucosal epithelial cells has been determined under basal conditions and in the presence of either theophylline or antidiuretic hormone (ADH); Under basal conditions and with PGE1 concentrations from 10(-8) to 10(-5) M no evidence of stimulation of water flow was observed, and with 10(-7) M PGE1 a significant inhibition was foundmcyclic AMP content under control conditions was 8 pmol/mg protein. It was 9 at 10(-8) M PGE1, 13 at 10(-7) M, 16 at 10(-6) M, and 23 at 10(-5) M. In the presence of theophylline, 10(-8) and 10(-7) M PGE1 inhibited the theophylline-induced water flow as expected. In contrast, 10(-6) and 10(-5) M PGE1 enhanced the rate of water flow. Theophylline increased cyclic AMP content from 8 to 18 pmol/mg protein. PGE1 in the presence of theophylline caused marked increases in cyclic AMP content; The content was 23 at 10(-7) M, 41 at 10(-6) M, and 130 at 10(-5) M; Thus PGE1 stimulates theophylline-induced water flow at cyclic AMP concentrations somewhere between 23 and 41 pmol/mg. Further evidence along these lines was obtained from experiments in which the effects of PGE1 on ADH-induced water flow were studied. Inhibitory effects of PGE1 were not observed at concentrations of PGE1 which raised the level of intracellular cyclic AMP to 30 pmol/mg protein or higher. These results were obtained despite the fact that all four concentrations of PGE1 tested were found capable of inhibiting ADH-induced water flow under appropriate conditions or, in other words, were inhibiting the adenylate cyclase controlling water flow, Thus the increase in cyclic AMP content in response to PGE1 is not derived from this enzyme. Thus the stimulation of water flow by PGE1 in the presence of theophylline is thought to be caused by cyclic AMP spilling over from one compartment to the water flow compartment. No evidence was obtained to directly suggest spillover into the sodium transport compartment. Furthermore evidence is discussed to suggest that most of the cyclic AMP generated in the tissue does not originate from the enzyme controlling sodium transport. As cyclic AMP-stimulated water flow and sodium transport are thought to occur in one cell type, the granular cells, distinct pools of cyclic AMP are thought to be present in one and the same cell type. Thus one pool controls water flow and one controls sodium transport. With high concentrations of PGE1 in the presence of theophylline or high concentrations of ADH, the adenylate cyclase responsible for water flow is inhibited; However, PGE1 can stimulate a tissue adenylate cyclase to sufficiently high levels that cyclic AMP spills over into the water flow compartment and thus stimulates water flow." @default.
• W2085839596 created "2016-06-24" @default.
• W2085839596 creator A5008980513 @default.
• W2085839596 creator A5054057879 @default.
• W2085839596 creator A5083346283 @default.
• W2085839596 creator A5085352334 @default.
• W2085839596 date "1975-08-01" @default.
• W2085839596 modified "2023-10-18" @default.
• W2085839596 title "Stimulation of osmotic water flow in toad bladder by prostaglandin E1. Evidence for different compartments of cyclic AMP." @default.
• W2085839596 cites W1208939087 @default.
• W2085839596 cites W1775749144 @default.
• W2085839596 cites W1986469037 @default.
• W2085839596 cites W1996532511 @default.
• W2085839596 cites W2004414721 @default.
• W2085839596 cites W2014359221 @default.
• W2085839596 cites W2014695756 @default.
• W2085839596 cites W2022783689 @default.
• W2085839596 cites W2024602240 @default.
• W2085839596 cites W2026944139 @default.
• W2085839596 cites W2033425048 @default.
• W2085839596 cites W2034379526 @default.
• W2085839596 cites W2049301596 @default.
• W2085839596 cites W2065702207 @default.
• W2085839596 cites W2140081505 @default.
• W2085839596 cites W2166944163 @default.
• W2085839596 cites W2168844637 @default.
• W2085839596 cites W2410349718 @default.
• W2085839596 cites W2422162888 @default.
• W2085839596 cites W2433596901 @default.
• W2085839596 cites W2467636150 @default.
• W2085839596 cites W45574617 @default.
• W2085839596 doi "https://doi.org/10.1172/jci108088" @default.
• W2085839596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/436582" @default.
• W2085839596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/168231" @default.
• W2085839596 hasPublicationYear "1975" @default.
• W2085839596 type Work @default.
• W2085839596 sameAs 2085839596 @default.
• W2085839596 citedByCount "32" @default.
• W2085839596 countsByYear W20858395962015 @default.
• W2085839596 crossrefType "journal-article" @default.
• W2085839596 hasAuthorship W2085839596A5008980513 @default.
• W2085839596 hasAuthorship W2085839596A5054057879 @default.
• W2085839596 hasAuthorship W2085839596A5083346283 @default.
• W2085839596 hasAuthorship W2085839596A5085352334 @default.
• W2085839596 hasBestOaLocation W20858395961 @default.
• W2085839596 hasConcept C126322002 @default.
• W2085839596 hasConcept C127413603 @default.
• W2085839596 hasConcept C134018914 @default.
• W2085839596 hasConcept C185592680 @default.
• W2085839596 hasConcept C24998067 @default.
• W2085839596 hasConcept C2776370428 @default.
• W2085839596 hasConcept C2778095195 @default.
• W2085839596 hasConcept C2778166480 @default.
• W2085839596 hasConcept C2779420931 @default.
• W2085839596 hasConcept C2779837120 @default.
• W2085839596 hasConcept C2780664492 @default.
• W2085839596 hasConcept C2988574769 @default.
• W2085839596 hasConcept C71924100 @default.
• W2085839596 hasConcept C86803240 @default.
• W2085839596 hasConcept C87717796 @default.
• W2085839596 hasConceptScore W2085839596C126322002 @default.
• W2085839596 hasConceptScore W2085839596C127413603 @default.
• W2085839596 hasConceptScore W2085839596C134018914 @default.
• W2085839596 hasConceptScore W2085839596C185592680 @default.
• W2085839596 hasConceptScore W2085839596C24998067 @default.
• W2085839596 hasConceptScore W2085839596C2776370428 @default.
• W2085839596 hasConceptScore W2085839596C2778095195 @default.
• W2085839596 hasConceptScore W2085839596C2778166480 @default.
• W2085839596 hasConceptScore W2085839596C2779420931 @default.
• W2085839596 hasConceptScore W2085839596C2779837120 @default.
• W2085839596 hasConceptScore W2085839596C2780664492 @default.
• W2085839596 hasConceptScore W2085839596C2988574769 @default.
• W2085839596 hasConceptScore W2085839596C71924100 @default.
• W2085839596 hasConceptScore W2085839596C86803240 @default.
• W2085839596 hasConceptScore W2085839596C87717796 @default.
• W2085839596 hasIssue "2" @default.
• W2085839596 hasLocation W20858395961 @default.
• W2085839596 hasLocation W20858395962 @default.
• W2085839596 hasLocation W20858395963 @default.
• W2085839596 hasLocation W20858395964 @default.
• W2085839596 hasLocation W20858395965 @default.
• W2085839596 hasOpenAccess W2085839596 @default.
• W2085839596 hasPrimaryLocation W20858395961 @default.
• W2085839596 hasRelatedWork W1964596246 @default.
• W2085839596 hasRelatedWork W1992645942 @default.
• W2085839596 hasRelatedWork W2003587549 @default.
• W2085839596 hasRelatedWork W2033746374 @default.
• W2085839596 hasRelatedWork W2040558763 @default.
• W2085839596 hasRelatedWork W2071155830 @default.
• W2085839596 hasRelatedWork W2085839596 @default.
• W2085839596 hasRelatedWork W2089952601 @default.
• W2085839596 hasRelatedWork W2146713571 @default.
• W2085839596 hasRelatedWork W2234994983 @default.
• W2085839596 hasVolume "56" @default.
• W2085839596 isParatext "false" @default.
• W2085839596 isRetracted "false" @default.
• W2085839596 magId "2085839596" @default.
• W2085839596 workType "article" @default.