Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085840157> ?p ?o ?g. }
- W2085840157 endingPage "10" @default.
- W2085840157 startingPage "1" @default.
- W2085840157 abstract "Figure 2 illustrates a suggested mechanism of carcinogenesis. This scheme takes into account the effect of carcinogens at different integration levels: subcellular, tissue, and organism. Any of these levels may be age dependent. Age-associated changes in the activity of enzymes responsible for activation and inactivation of carcinogens, and variations in concentrations of lipids and proteins contributing to the transport of carcinogenic agents into cells, may play an important role in the modifying effect of age on carcinogenesis. The effects of age-associated changes in DNA repair need clarification. However, they are thought to exert a permissive influence on the age-associated rise in tumor incidence. It seems that proliferative activity of target tissues is the important modifying factor of carcinogenesis. Age-related changes of regulation at tissue and organism levels are also powerful factors in carcinogenesis modification. Age-dependent changes in the neuroendocrine system provide conditions for metabolic immunodepression and promotion of carcinogenesis. On the other hand, carcinogens per se (especially chemical and radiological) may intensify aging processes in the organism. Normalization, by drugs, of age-associated shifts requiring synthetic and energetic changes of a transformed tumor cells, and of immunological shifts, may exert both antitumor and geroprotective effects." @default.
- W2085840157 created "2016-06-24" @default.
- W2085840157 creator A5027331206 @default.
- W2085840157 creator A5061862694 @default.
- W2085840157 creator A5062719301 @default.
- W2085840157 date "2009-02-27" @default.
- W2085840157 modified "2023-10-14" @default.
- W2085840157 title "Carcinogenesis and Aging" @default.
- W2085840157 cites W1185699971 @default.
- W2085840157 cites W121259540 @default.
- W2085840157 cites W1481235255 @default.
- W2085840157 cites W1483194800 @default.
- W2085840157 cites W1489762713 @default.
- W2085840157 cites W1517011195 @default.
- W2085840157 cites W1521278324 @default.
- W2085840157 cites W1526436623 @default.
- W2085840157 cites W1533440148 @default.
- W2085840157 cites W1551240089 @default.
- W2085840157 cites W1555256966 @default.
- W2085840157 cites W1557146542 @default.
- W2085840157 cites W1568511841 @default.
- W2085840157 cites W1571527269 @default.
- W2085840157 cites W1580887576 @default.
- W2085840157 cites W1583815688 @default.
- W2085840157 cites W1591440253 @default.
- W2085840157 cites W1607033099 @default.
- W2085840157 cites W171699507 @default.
- W2085840157 cites W1747682810 @default.
- W2085840157 cites W1769515749 @default.
- W2085840157 cites W1793403192 @default.
- W2085840157 cites W179525646 @default.
- W2085840157 cites W1821990308 @default.
- W2085840157 cites W1826426338 @default.
- W2085840157 cites W1828290058 @default.
- W2085840157 cites W1855028888 @default.
- W2085840157 cites W1875202526 @default.
- W2085840157 cites W1892170525 @default.
- W2085840157 cites W1904466522 @default.
- W2085840157 cites W1908327267 @default.
- W2085840157 cites W1909511722 @default.
- W2085840157 cites W1910332915 @default.
- W2085840157 cites W1912415904 @default.
- W2085840157 cites W1919107299 @default.
- W2085840157 cites W1941620051 @default.
- W2085840157 cites W1945995775 @default.
- W2085840157 cites W1959139651 @default.
- W2085840157 cites W1964369626 @default.
- W2085840157 cites W1966997057 @default.
- W2085840157 cites W1967228974 @default.
- W2085840157 cites W1967961702 @default.
- W2085840157 cites W1968706786 @default.
- W2085840157 cites W1969188969 @default.
- W2085840157 cites W1970408823 @default.
- W2085840157 cites W1970731848 @default.
- W2085840157 cites W1970788128 @default.
- W2085840157 cites W1972393486 @default.
- W2085840157 cites W1973769059 @default.
- W2085840157 cites W1973995986 @default.
- W2085840157 cites W1974135428 @default.
- W2085840157 cites W1976867487 @default.
- W2085840157 cites W1979757394 @default.
- W2085840157 cites W1979882146 @default.
- W2085840157 cites W1980660526 @default.
- W2085840157 cites W1980922228 @default.
- W2085840157 cites W1981035795 @default.
- W2085840157 cites W1981187755 @default.
- W2085840157 cites W1982882074 @default.
- W2085840157 cites W1982981881 @default.
- W2085840157 cites W1983060585 @default.
- W2085840157 cites W1984787770 @default.
- W2085840157 cites W1985209489 @default.
- W2085840157 cites W1986905665 @default.
- W2085840157 cites W1987356089 @default.
- W2085840157 cites W1987701269 @default.
- W2085840157 cites W1989358225 @default.
- W2085840157 cites W1991167126 @default.
- W2085840157 cites W1995111715 @default.
- W2085840157 cites W1995711971 @default.
- W2085840157 cites W1997894805 @default.
- W2085840157 cites W1998945538 @default.
- W2085840157 cites W1999049707 @default.
- W2085840157 cites W1999572058 @default.
- W2085840157 cites W2000326409 @default.
- W2085840157 cites W2000583617 @default.
- W2085840157 cites W2003111377 @default.
- W2085840157 cites W2004172605 @default.
- W2085840157 cites W2008229098 @default.
- W2085840157 cites W2008372753 @default.
- W2085840157 cites W2010524704 @default.
- W2085840157 cites W2011062026 @default.
- W2085840157 cites W2011260171 @default.
- W2085840157 cites W2012424975 @default.
- W2085840157 cites W2013854344 @default.
- W2085840157 cites W2015049966 @default.
- W2085840157 cites W2017790973 @default.
- W2085840157 cites W2020261489 @default.
- W2085840157 cites W2021236319 @default.
- W2085840157 cites W2021402593 @default.