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- W2085842563 abstract "Tuberculosis (TB) has different clinical presentations. Pulmonary TB affects only the lungs and exhibits variable anti-mycobacterial immune responses. Pleural TB is a localized disease with a strong immune response. Miliary TB is a disseminated form with poor immune response. Cytokines play a pivotal role in anti-mycobacterial response and may determine the type of TB. Thus, gene polymorphisms associated with cytokine production may be associated with clinical presentations of TB. In this study, 54 tuberculin-negative healthy controls, 81 tuberculin-positive healthy controls, 140 patients with pulmonary TB, 30 with pleural TB and 20 with miliary TB were studied. Single nucleotide polymorphisms were typed for tumour necrosis factor-α, interferon-γ (IFN-γ), transforming growth factor-β1, interleukin-10 (IL-10) and interleukin-6 by sequence-specific primer polymerase chain reaction (SSP-PCR). Allelic, genotypic and haplotypic associations with clinical forms of TB were evaluated. IL-10 −1082 A/A genotype and IFNγ+874 T allele were associated with pleural TB. Seventy-five extended genotypes were found; two differed between patients and controls, and two between groups of patients. Results suggest that IL-10 low-producer polymorphism and IFN-γ high-producer polymorphism are associated with pleural TB." @default.
- W2085842563 created "2016-06-24" @default.
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- W2085842563 date "2006-01-01" @default.
- W2085842563 modified "2023-10-16" @default.
- W2085842563 title "Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis" @default.
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- W2085842563 doi "https://doi.org/10.1016/j.tube.2005.03.001" @default.
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