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- W2085857996 abstract "Neurons of the medullary raphe nuclei contain multiple neurotransmitters including the monoamine neurotransmitter serotonin (5-HT) and the tachykinin substance P (SP). Previously, we showed that inhibition of serotonin synthesis increased levels of mRNA coding for preprotachykinin (PPT), the prohormone precursor of SP (P. D. Walker et al., 1990, Mol. Brain Res. 8: 113–119). To determine whether augmented serotonin transmission would have the predictably opposite effect, we have examined the effects of a 5-HT uptake blocker (zimelidine) and a monoamine oxidase inhibitor (clorgyline) on levels of PPT mRNA. We looked also at the effect of zimelidine and clorgyline on levels of ventral spinal cord substance P-like immunoreactivity (SP-LI) of the same animals. Both zimelidine and clorgyline decreased levels of PPT mRNA in medullary raphe neurons and SP-LI in the ventral spinal cord. The effect on message was transient with levels returning to control by 14 days of drug treatment. These results show that increases in synaptic 5-HT cause transient decreases in PPT mRNA and SP-LI" @default.
- W2085857996 created "2016-06-24" @default.
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- W2085857996 date "1991-04-01" @default.
- W2085857996 modified "2023-09-23" @default.
- W2085857996 title "Both zimelidine and clorgyline decrease preprotachykinin mRNA in adult medullary raphe nuclei" @default.
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- W2085857996 doi "https://doi.org/10.1016/1044-7431(91)90006-a" @default.
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