Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085867711> ?p ?o ?g. }
- W2085867711 endingPage "260" @default.
- W2085867711 startingPage "253" @default.
- W2085867711 abstract "We describe the cloning and expression of Dobrava hantavirus (DOBV) nucleocapsid proteins and a truncated form consisting of the first 118 N-terminal amino acids, and the capacity of these <i>E. coli</i> ICONE 200-expressed recombinant proteins (rNp) to induce a protective immune response against DOBV in mice. As an alternative carrier protein, the outer membrane protein A derived from <i>Klebsiella pneumoniae</i> (rP40) has been coupled to different rNp constructs. All recombinant proteins were found to be highly immunogenic after three immunizations of rNp. The immunizations resulted in the induction of a strong Np-specific IgG response with a predominance of IgG1 over IgG2b and IgG2a, suggesting a mixed Th1/Th2 cell involvement. A specific IgG3 response could not be detected. Mice immunized with recombinant DOBV rNp without rP40 showed lower nucleocapsid-specific antibody responses in comparison with the rP40-conjugated constructs, but all mice were found to be protected against DOBV challenge. Our results indicate that the rNp constructs coupled to rP40, represent promising vaccine candidates." @default.
- W2085867711 created "2016-06-24" @default.
- W2085867711 creator A5008139614 @default.
- W2085867711 creator A5016870773 @default.
- W2085867711 creator A5023438676 @default.
- W2085867711 creator A5027877793 @default.
- W2085867711 creator A5031307879 @default.
- W2085867711 creator A5041939518 @default.
- W2085867711 creator A5044984230 @default.
- W2085867711 date "2006-01-01" @default.
- W2085867711 modified "2023-10-18" @default.
- W2085867711 title "Truncated Recombinant Dobrava Hantavirus Nucleocapsid Proteins Induce Strong, Long-Lasting Immune Responses in Mice" @default.
- W2085867711 cites W1496259637 @default.
- W2085867711 cites W1597281487 @default.
- W2085867711 cites W1657458573 @default.
- W2085867711 cites W1972213702 @default.
- W2085867711 cites W1972944084 @default.
- W2085867711 cites W1978302676 @default.
- W2085867711 cites W1980104757 @default.
- W2085867711 cites W1987163064 @default.
- W2085867711 cites W1987657010 @default.
- W2085867711 cites W2000888410 @default.
- W2085867711 cites W2003625203 @default.
- W2085867711 cites W2005433224 @default.
- W2085867711 cites W2005551296 @default.
- W2085867711 cites W2008062941 @default.
- W2085867711 cites W2013263076 @default.
- W2085867711 cites W2039107470 @default.
- W2085867711 cites W2040712691 @default.
- W2085867711 cites W2047809460 @default.
- W2085867711 cites W2056540103 @default.
- W2085867711 cites W2062749454 @default.
- W2085867711 cites W2064489277 @default.
- W2085867711 cites W2065175993 @default.
- W2085867711 cites W2066152299 @default.
- W2085867711 cites W2074418629 @default.
- W2085867711 cites W2083282434 @default.
- W2085867711 cites W2083613414 @default.
- W2085867711 cites W2087579076 @default.
- W2085867711 cites W2092577288 @default.
- W2085867711 cites W2104369038 @default.
- W2085867711 cites W2105161591 @default.
- W2085867711 cites W2111227085 @default.
- W2085867711 cites W2129588141 @default.
- W2085867711 cites W2153843590 @default.
- W2085867711 cites W2158624940 @default.
- W2085867711 cites W2163659778 @default.
- W2085867711 doi "https://doi.org/10.1159/000093454" @default.
- W2085867711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16714853" @default.
- W2085867711 hasPublicationYear "2006" @default.
- W2085867711 type Work @default.
- W2085867711 sameAs 2085867711 @default.
- W2085867711 citedByCount "17" @default.
- W2085867711 countsByYear W20858677112014 @default.
- W2085867711 countsByYear W20858677112015 @default.
- W2085867711 countsByYear W20858677112017 @default.
- W2085867711 countsByYear W20858677112019 @default.
- W2085867711 countsByYear W20858677112020 @default.
- W2085867711 countsByYear W20858677112021 @default.
- W2085867711 crossrefType "journal-article" @default.
- W2085867711 hasAuthorship W2085867711A5008139614 @default.
- W2085867711 hasAuthorship W2085867711A5016870773 @default.
- W2085867711 hasAuthorship W2085867711A5023438676 @default.
- W2085867711 hasAuthorship W2085867711A5027877793 @default.
- W2085867711 hasAuthorship W2085867711A5031307879 @default.
- W2085867711 hasAuthorship W2085867711A5041939518 @default.
- W2085867711 hasAuthorship W2085867711A5044984230 @default.
- W2085867711 hasConcept C104317684 @default.
- W2085867711 hasConcept C153911025 @default.
- W2085867711 hasConcept C159047783 @default.
- W2085867711 hasConcept C159654299 @default.
- W2085867711 hasConcept C203014093 @default.
- W2085867711 hasConcept C2522874641 @default.
- W2085867711 hasConcept C2775992772 @default.
- W2085867711 hasConcept C40767141 @default.
- W2085867711 hasConcept C54355233 @default.
- W2085867711 hasConcept C86803240 @default.
- W2085867711 hasConcept C8891405 @default.
- W2085867711 hasConceptScore W2085867711C104317684 @default.
- W2085867711 hasConceptScore W2085867711C153911025 @default.
- W2085867711 hasConceptScore W2085867711C159047783 @default.
- W2085867711 hasConceptScore W2085867711C159654299 @default.
- W2085867711 hasConceptScore W2085867711C203014093 @default.
- W2085867711 hasConceptScore W2085867711C2522874641 @default.
- W2085867711 hasConceptScore W2085867711C2775992772 @default.
- W2085867711 hasConceptScore W2085867711C40767141 @default.
- W2085867711 hasConceptScore W2085867711C54355233 @default.
- W2085867711 hasConceptScore W2085867711C86803240 @default.
- W2085867711 hasConceptScore W2085867711C8891405 @default.
- W2085867711 hasIssue "5" @default.
- W2085867711 hasLocation W20858677111 @default.
- W2085867711 hasLocation W20858677112 @default.
- W2085867711 hasOpenAccess W2085867711 @default.
- W2085867711 hasPrimaryLocation W20858677111 @default.
- W2085867711 hasRelatedWork W1967277935 @default.
- W2085867711 hasRelatedWork W1997244264 @default.
- W2085867711 hasRelatedWork W2027499608 @default.
- W2085867711 hasRelatedWork W2065175993 @default.