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• W2085870808 abstract "The tumor suppressor Rb (retinoblastoma protein) is known to regulate p53-dependent apoptosis, but the mechanisms involved are unclear. In a rat fibroblast model, we previously observed that caspase inhibition potentiates p53-dependent apoptosis and prevents the Rb cleavage associated with p53 activation. These results suggested that a caspase(s) can antagonize p53-mediated apoptosis via the production of a protective Rb truncated form. Here, we identify caspase-9 as the caspase that interferes, upstream of the mitochondrion, with p53-induced apoptosis in both immortalized and primary fibroblasts. This caspase can be detected as a p38 processed form in living cells, in the absence of apoptosome formation and apoptotic signal. We also provide evidence that the involvement of caspase-9 in a pre-mitochondrial protective pathway results from the previously undescribed cleavage of Rb, at a LExD site, into a p76Rb form, which antagonizes p53-induced apoptosis. These results establish that a truncated form of Rb can display an antiapoptotic activity, rather than just being a by-product of Rb degradation." @default.
• W2085870808 created "2016-06-24" @default.
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• W2085870808 date "2005-02-21" @default.
• W2085870808 modified "2023-10-16" @default.
• W2085870808 title "Caspase-9 can antagonize p53-induced apoptosis by generating a p76Rb truncated form of Rb" @default.
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• W2085870808 doi "https://doi.org/10.1038/sj.onc.1208493" @default.
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