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- W2085877765 abstract "Three site‐directed mutants of human epidermal growth factor, Leu‐26 → Gly, Leu‐47 → Ala, and He‐23 → Thr, were examined for their ability to stimulate the protein‐tyrosine kinase activity of the epidermal growth factor receptor. The receptor binding affinities of the mutant growth factors were 20‐ to 50‐fold lower, as compared to wild‐type growth factor. At saturating concentrations of growth factor, the velocities of the phosphorylation of exogenously added substrate and receptor autophosphorylation were significantly lower with the mutant analogs, suggesting a partial ‘uncoupling’ of signal transduction. The mutant analogs were shown to compete directly with the binding of wild‐type, resulting in a decrease in growth factor‐stimulated kinase activity." @default.
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- W2085877765 date "1990-05-07" @default.
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- W2085877765 title "Analogs of human epidermal growth factor which partially inhibit the growth factor-dependent protein-tyrosine kinase activity of the epidermal growth factor receptor" @default.
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- W2085877765 doi "https://doi.org/10.1016/0014-5793(90)80776-f" @default.
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