FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085887994> ?p ?o ?g. }

• W2085887994 abstract "Focal segmental glomerulosclerosis (FSGS) is a glomerular scarring disease diagnosed mostly by kidney biopsy. Since there is currently no diagnostic test that can accurately predict steroid responsiveness in FSGS, prediction of the responsiveness of patients to steroid therapy with noninvasive means has become a critical issue. In the present study urinary proteomics was used as a noninvasive tool to discover potential predictive biomarkers. Urinary proteome of 10 patients (n = 6 steroid-sensitive, n = 4 steroid-resistant) with biopsy proven FSGS was analyzed using nano-LC-MS/MS and supervised multivariate statistical analysis was performed. Twenty one proteins were identified as discriminating species among which apolipoprotein A-1 and Matrix-remodeling protein 8 had the most drastic fold changes being over- and underrepresented, respectively, in steroid sensitive compared to steroid resistant urine samples. Gene ontology enrichment analysis revealed acute inflammatory response as the dominant biological process. The obtained results suggest a panel of predictive biomarkers for FSGS. Proteins involved in the inflammatory response are shown to be implicated in the responsiveness. As a tool for biomarker discovery, urinary proteomics is especially fruitful in the area of prediction of responsiveness to drugs. Further validation of these biomarkers is however needed." @default.
• W2085887994 created "2016-06-24" @default.
• W2085887994 creator A5015270508 @default.
• W2085887994 creator A5019526638 @default.
• W2085887994 creator A5069457273 @default.
• W2085887994 creator A5077638467 @default.
• W2085887994 creator A5078864299 @default.
• W2085887994 creator A5087312929 @default.
• W2085887994 creator A5091836453 @default.
• W2085887994 date "2014-09-02" @default.
• W2085887994 modified "2023-10-09" @default.
• W2085887994 title "Predictive urinary biomarkers for steroid-resistant and steroid-sensitive focal segmental glomerulosclerosis using high resolution mass spectrometry and multivariate statistical analysis" @default.
• W2085887994 cites W1174340274 @default.
• W2085887994 cites W1569219037 @default.
• W2085887994 cites W1981410669 @default.
• W2085887994 cites W1987559400 @default.
• W2085887994 cites W1990694891 @default.
• W2085887994 cites W1993332800 @default.
• W2085887994 cites W1994069320 @default.
• W2085887994 cites W1996286210 @default.
• W2085887994 cites W2005162839 @default.
• W2085887994 cites W2005376830 @default.
• W2085887994 cites W2007180351 @default.
• W2085887994 cites W2012645854 @default.
• W2085887994 cites W2013829288 @default.
• W2085887994 cites W2015667100 @default.
• W2085887994 cites W2027161422 @default.
• W2085887994 cites W2033126244 @default.
• W2085887994 cites W2036814376 @default.
• W2085887994 cites W2048927510 @default.
• W2085887994 cites W2056024130 @default.
• W2085887994 cites W2058124574 @default.
• W2085887994 cites W2074946617 @default.
• W2085887994 cites W2081406581 @default.
• W2085887994 cites W2084544719 @default.
• W2085887994 cites W2089391563 @default.
• W2085887994 cites W2093502143 @default.
• W2085887994 cites W2093540538 @default.
• W2085887994 cites W2099100522 @default.
• W2085887994 cites W2102878417 @default.
• W2085887994 cites W2106132002 @default.
• W2085887994 cites W2108488321 @default.
• W2085887994 cites W2111471750 @default.
• W2085887994 cites W2122683221 @default.
• W2085887994 cites W2127938920 @default.
• W2085887994 cites W2132228009 @default.
• W2085887994 cites W2136505569 @default.
• W2085887994 cites W2143283561 @default.
• W2085887994 cites W2152176378 @default.
• W2085887994 cites W2155746061 @default.
• W2085887994 cites W2158090936 @default.
• W2085887994 cites W2158698691 @default.
• W2085887994 cites W2166221168 @default.
• W2085887994 cites W2167051832 @default.
• W2085887994 cites W2168481764 @default.
• W2085887994 cites W2168537911 @default.
• W2085887994 cites W2315817088 @default.
• W2085887994 cites W2323753285 @default.
• W2085887994 cites W2416665437 @default.
• W2085887994 cites W2503993098 @default.
• W2085887994 doi "https://doi.org/10.1186/1471-2369-15-141" @default.
• W2085887994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4236676" @default.
• W2085887994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25182141" @default.
• W2085887994 hasPublicationYear "2014" @default.
• W2085887994 type Work @default.
• W2085887994 sameAs 2085887994 @default.
• W2085887994 citedByCount "25" @default.
• W2085887994 countsByYear W20858879942015 @default.
• W2085887994 countsByYear W20858879942016 @default.
• W2085887994 countsByYear W20858879942017 @default.
• W2085887994 countsByYear W20858879942018 @default.
• W2085887994 countsByYear W20858879942019 @default.
• W2085887994 countsByYear W20858879942022 @default.
• W2085887994 countsByYear W20858879942023 @default.
• W2085887994 crossrefType "journal-article" @default.
• W2085887994 hasAuthorship W2085887994A5015270508 @default.
• W2085887994 hasAuthorship W2085887994A5019526638 @default.
• W2085887994 hasAuthorship W2085887994A5069457273 @default.
• W2085887994 hasAuthorship W2085887994A5077638467 @default.
• W2085887994 hasAuthorship W2085887994A5078864299 @default.
• W2085887994 hasAuthorship W2085887994A5087312929 @default.
• W2085887994 hasAuthorship W2085887994A5091836453 @default.
• W2085887994 hasBestOaLocation W20858879941 @default.
• W2085887994 hasConcept C104317684 @default.
• W2085887994 hasConcept C124535831 @default.
• W2085887994 hasConcept C126322002 @default.
• W2085887994 hasConcept C126894567 @default.
• W2085887994 hasConcept C134018914 @default.
• W2085887994 hasConcept C2777747828 @default.
• W2085887994 hasConcept C2778415529 @default.
• W2085887994 hasConcept C2780091579 @default.
• W2085887994 hasConcept C2780368995 @default.
• W2085887994 hasConcept C2780902042 @default.
• W2085887994 hasConcept C2781197716 @default.
• W2085887994 hasConcept C46111723 @default.
• W2085887994 hasConcept C54847362 @default.
• W2085887994 hasConcept C55493867 @default.
• W2085887994 hasConcept C71315377 @default.
• W2085887994 hasConcept C71924100 @default.
• W2085887994 hasConcept C77411442 @default.

• next