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• W2085890493 abstract "Colchicine is a known tubulin binding agent enabling necrosis in tumors. A novel tubulin-directed DO3A-colchicine conjugate and its Gd(III) complex were prepared from N-deacetylcolchicine, coupling alkaloid and polyaza-alicyclic functions via a peptide coupling methodology. The longitudinal proton relaxivity of the Gd(III) complex in water at 4.7 T is 2.86 mM(-1) s(-1) and a similar efficacy as colchicine towards ovarian carcinoma cells in vitro." @default.
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• W2085890493 date "2011-06-01" @default.
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• W2085890493 title "Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features" @default.
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• W2085890493 doi "https://doi.org/10.1016/j.bmcl.2011.04.014" @default.
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