Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085909899> ?p ?o ?g. }
- W2085909899 endingPage "699" @default.
- W2085909899 startingPage "685" @default.
- W2085909899 abstract "A series of novel cyclopropylamide analogues of combretastatin-A4 (CA-4) were designed and synthesized. Most of them had significant in vitro antiproliferative activities, particularly for compounds 7i4, 7c4, 8a4, and 8c4. Moreover, compound 8c4 was also equally potent against paclitaxel resistant cancer cells. Interestingly, the novel cyclopropylamide analogues had different binding mechanisms from CA-4. Instead of inhibiting tubulin polymerization, these CA-4 derivatives were able to stimulate tubulin polymerization. Flow cytometry revealed that compound 8c4 arrested A549 cancer cells in the G2/M phase and resulted in cellular apoptosis. Further immunofluorescence assays revealed that compound 8c4 induced mitotic arrest in A549 cells through disrupting microtubule dynamics. In addition, compound 8c4 also effectively inhibited the tumor growth in the A549 xenograft model without causing significant loss of body weight. Compound 8c4 represents a novel class of microtubule-stabilizing agent and can be used as a promising lead for the development of new antitumor agents." @default.
- W2085909899 created "2016-06-24" @default.
- W2085909899 creator A5001945961 @default.
- W2085909899 creator A5017100408 @default.
- W2085909899 creator A5018944973 @default.
- W2085909899 creator A5035701638 @default.
- W2085909899 creator A5048496562 @default.
- W2085909899 creator A5057117256 @default.
- W2085909899 creator A5057853505 @default.
- W2085909899 creator A5060125356 @default.
- W2085909899 creator A5065379006 @default.
- W2085909899 creator A5067106762 @default.
- W2085909899 creator A5072036320 @default.
- W2085909899 creator A5078632164 @default.
- W2085909899 creator A5082494084 @default.
- W2085909899 date "2013-01-28" @default.
- W2085909899 modified "2023-10-17" @default.
- W2085909899 title "Design and Synthesis of Cyclopropylamide Analogues of Combretastatin-A4 as Novel Microtubule-Stabilizing Agents" @default.
- W2085909899 cites W1570441204 @default.
- W2085909899 cites W1963878289 @default.
- W2085909899 cites W1971579914 @default.
- W2085909899 cites W1999077006 @default.
- W2085909899 cites W1999965967 @default.
- W2085909899 cites W2009587543 @default.
- W2085909899 cites W2014184691 @default.
- W2085909899 cites W2024302518 @default.
- W2085909899 cites W2024930414 @default.
- W2085909899 cites W2029178312 @default.
- W2085909899 cites W2038361589 @default.
- W2085909899 cites W2039372826 @default.
- W2085909899 cites W2047543449 @default.
- W2085909899 cites W2047578735 @default.
- W2085909899 cites W2048383408 @default.
- W2085909899 cites W2048454522 @default.
- W2085909899 cites W2058131725 @default.
- W2085909899 cites W2058997498 @default.
- W2085909899 cites W2066515614 @default.
- W2085909899 cites W2067058482 @default.
- W2085909899 cites W2067299834 @default.
- W2085909899 cites W2070116427 @default.
- W2085909899 cites W2087799543 @default.
- W2085909899 cites W2088060757 @default.
- W2085909899 cites W2106521963 @default.
- W2085909899 cites W2107436374 @default.
- W2085909899 cites W2130986264 @default.
- W2085909899 cites W2145438844 @default.
- W2085909899 cites W2145516891 @default.
- W2085909899 cites W2147594462 @default.
- W2085909899 cites W2165629556 @default.
- W2085909899 cites W2166600497 @default.
- W2085909899 cites W2319364034 @default.
- W2085909899 cites W2950459206 @default.
- W2085909899 doi "https://doi.org/10.1021/jm301864s" @default.
- W2085909899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23356786" @default.
- W2085909899 hasPublicationYear "2013" @default.
- W2085909899 type Work @default.
- W2085909899 sameAs 2085909899 @default.
- W2085909899 citedByCount "58" @default.
- W2085909899 countsByYear W20859098992013 @default.
- W2085909899 countsByYear W20859098992014 @default.
- W2085909899 countsByYear W20859098992015 @default.
- W2085909899 countsByYear W20859098992016 @default.
- W2085909899 countsByYear W20859098992017 @default.
- W2085909899 countsByYear W20859098992018 @default.
- W2085909899 countsByYear W20859098992019 @default.
- W2085909899 countsByYear W20859098992020 @default.
- W2085909899 countsByYear W20859098992021 @default.
- W2085909899 countsByYear W20859098992022 @default.
- W2085909899 countsByYear W20859098992023 @default.
- W2085909899 crossrefType "journal-article" @default.
- W2085909899 hasAuthorship W2085909899A5001945961 @default.
- W2085909899 hasAuthorship W2085909899A5017100408 @default.
- W2085909899 hasAuthorship W2085909899A5018944973 @default.
- W2085909899 hasAuthorship W2085909899A5035701638 @default.
- W2085909899 hasAuthorship W2085909899A5048496562 @default.
- W2085909899 hasAuthorship W2085909899A5057117256 @default.
- W2085909899 hasAuthorship W2085909899A5057853505 @default.
- W2085909899 hasAuthorship W2085909899A5060125356 @default.
- W2085909899 hasAuthorship W2085909899A5065379006 @default.
- W2085909899 hasAuthorship W2085909899A5067106762 @default.
- W2085909899 hasAuthorship W2085909899A5072036320 @default.
- W2085909899 hasAuthorship W2085909899A5078632164 @default.
- W2085909899 hasAuthorship W2085909899A5082494084 @default.
- W2085909899 hasConcept C121608353 @default.
- W2085909899 hasConcept C153911025 @default.
- W2085909899 hasConcept C185592680 @default.
- W2085909899 hasConcept C190283241 @default.
- W2085909899 hasConcept C202751555 @default.
- W2085909899 hasConcept C20418707 @default.
- W2085909899 hasConcept C2777292972 @default.
- W2085909899 hasConcept C2778275628 @default.
- W2085909899 hasConcept C2909009945 @default.
- W2085909899 hasConcept C29537977 @default.
- W2085909899 hasConcept C54355233 @default.
- W2085909899 hasConcept C553184892 @default.
- W2085909899 hasConcept C55493867 @default.
- W2085909899 hasConcept C81729549 @default.
- W2085909899 hasConcept C84425145 @default.