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- W2085919996 abstract "Thrombolytic therapy with intravenous alteplase for ischemic stroke is restricted by guidelines, because of the risk of hemorrhage, especially in the brain, and only a small number of selected patients are being treated. Findings from meta analyses and post licensing experience suggest that more subjects, who otherwise have a poor predicted outcome without treatment, might benefit from intravenous. We retrospectively assessed clinical safety of the IV stroke thrombolysis beyond guidelines in 20 patients out of 140 total patients thrombolysed by IV rtPA in our department. Patient eligible for thrombolysis within 3 h were selected by CT or MRI and beyond 3 h only by MRI brain. Imaging study was done at the time of presentation and after 24 h to rule out symptomatic ICH. We have not recorded any symptomatic ICH in any patients which we thrombolysed beyond guideline. Two patients had asymptomatic hemorrhagic transformation. This document does not intend to change the guidelines but reviews the literature on the use of intravenous alteplase for stroke beyond guidelines and in particular conditions which help in more and more patients can be benefited by stroke thrombolysis." @default.
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- W2085919996 date "2013-09-01" @default.
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- W2085919996 title "Stroke IV thrombolysis beyond limitations; case series and review of literature" @default.
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- W2085919996 doi "https://doi.org/10.1016/j.apme.2013.08.004" @default.
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