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• W2085931091 abstract "We investigated the effect of glutamine supplementation on plasma glutamine (Gln), glutamate (Glu), and whole-blood glutathione (GSH) concentrations in human volunteers.Subjects first adapted to a standard diet with known intakes of protein, total GSH, cysteine, methionine, and total Glu (Glu values include Glu and Gln) for 3 d. Plasma Gln, Glu, and whole-blood GSH levels were then measured at 4-h intervals over 24 h. Supplemental oral Gln (0.3 g x kg(-1) x d(-1)) was ingested for 10 d and then 24-h plasma levels of Gln, Glu, and whole-blood GSH were measured.The plasma concentrations of Glu (116%; P = 0.006) and Gln (20%; P = 0.046) were significantly higher, whereas concentrations of GSH were significantly lower (37%; P = 0.00091) after oral Gln supplementation.Oral Gln increases Glu and Gln levels in plasma of healthy subjects but does not increase GSH red cell (whole-blood) levels. Thus, GSH biosynthesis and preservation of GHS stores in red blood cells may involve rate-limiting substrates other than Gln." @default.
• W2085931091 created "2016-06-24" @default.
• W2085931091 creator A5011333575 @default.
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• W2085931091 date "2002-05-01" @default.
• W2085931091 modified "2023-09-27" @default.
• W2085931091 title "Impact of oral l-glutamine on glutathione, glutamine, and glutamate blood levels in volunteers" @default.
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• W2085931091 doi "https://doi.org/10.1016/s0899-9007(02)00774-8" @default.
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