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- W2085932626 abstract "Transcripts from the α-, β- and δ-tropomyosin genes were studied during development of pure cultures of rat neurons, astrocytes and oligodendrocytes. The three cell types contained five α-tropomyosin messengers, produced using both alternative promoters and splicing; one was specific for mature neurons. The β-tropomyosin gene is expressed only in astrocytes and the δ-tropomyosin gene in all three cell types, especially in immature cells. Most of the tropomyosin isoforms are highly cell-specific. Their developmental regulation involves either differential expression of genes, in neurons and oligodendrocytes, and/or changes in alternative splicing, in astrocytes. δ-Tropomyosin (TM-4) may be important during the growth of neuronal and glial cell processes, while specialized isoforms such as the neuron-specific α-tropomyosin TMBr-3 may be involved in the function or plasticity of the mature cells." @default.
- W2085932626 created "2016-06-24" @default.
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- W2085932626 date "1993-04-01" @default.
- W2085932626 modified "2023-10-18" @default.
- W2085932626 title "The expression of tropomyosin genes in pure cultures of rat neurons, astrocytes and oligodendrocytes is highly cell-type specific and strongly regulated during development" @default.
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- W2085932626 doi "https://doi.org/10.1016/0169-328x(93)90175-o" @default.
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