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- W2085944172 abstract "Letters1 July 1992Hepatotoxicity of Fluorouracil with N-Phosphonacetyl-L-AspartateUnne Stenram, MD, PhDUnne Stenram, MD, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-1-90_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Kemeny and colleagues (1) have reported a new side effect in patients given bolus fluorouracil andN-phosphonacetyl-L-aspartate (PALA). They cannot explain why this effect did not occur with infusional fluorouracil and PALA. As the authors state, the toxicity must be caused by the incorporation of fluorouracil into liver RNA. Little DNA synthesis occurs in the liver. Valeriote and Santelli (2) believe that bolus doses of fluorouracil are the optimal mode of administration for RNA cytotoxicity. In studies in rats, we found a general tendency toward higher incorporation of fluorouracil into the RNA of tumor and normal tissue,...References1. KemenySeiterMartinUrmacherNiedzwieckiKurtz NKDCDR. A new syndrome: ascites, hyperbilirubinemia, and hypoalbuminemia after biochemical modulation of fluorouracil with N-phosphonacetyl-L-aspartate (PALA). Ann Intern Med. 1991;115:946-51. LinkGoogle Scholar2. ValerioteSantelli FG. 5-fluorouracil (FUra). Pharmacol Ther. 1984; 24:107-32. CrossrefMedlineGoogle Scholar3. ErichsenChristenssonJacobssonJönssonStenram CPBPU. Effects of dosage and infusion time on the incorporation of 5-fluorouracil into DNA and RNA of normal tissues and an adenocarcinoma transplanted to rat liver. J Surg Oncol. 1988;38:155-9. CrossrefMedlineGoogle Scholar4. ErichsenChristenssonJakobssonErikssonYngnerJönsson CPBGTP. Effect of N-phosphonacetyl-L-aspartate and D-glucosamine on the incorporation of 5-fluorouridine into normal tissues and an adenocarcinoma in the rat. Anticancer Res. 1987;7:77-80. MedlineGoogle Scholar5. Stenram U. Cytological, radioautographic and ultrastructural studies on the effect of 5-fluorouracil on rat liver. Z Zellforsch. 1966;71:207-16. CrossrefMedlineGoogle Scholar1. KemenySeiterMartinUrmacherNiedzwieckiKurtz NKDCDR. A new syndrome: ascites, hyperbilirubinemia, and hypoalbuminemia after biochemical modulation of fluorouracil with N-phosphonacetyl-L-aspartate (PALA). Ann Intern Med. 1991;115:946-51. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lund University S-221 85 Lund Sweden PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1992Volume 117, Issue 1Page: 90-91KeywordsDNA synthesisLiverRNAToxicity Issue Published: 1 July 1992 PDF downloadLoading ..." @default.
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- W2085944172 title "Hepatotoxicity of Fluorouracil with <i>N</i>-Phosphonacetyl-<scp>L</scp>-Aspartate" @default.
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