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- W2085944730 endingPage "e46316" @default.
- W2085944730 startingPage "e46316" @default.
- W2085944730 abstract "A-kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) and localize the holoenzyme to discrete signaling microdomains in multiple subcellular compartments. Despite emerging evidence for a nuclear pool of PKA that rapidly responds to activation of the PKA signaling cascade, only a few AKAPs have been identified that localize to the nucleus. Here we show a PKA-binding domain in the amino terminus of Chd8, and demonstrate subcellular colocalization of Chd8 with RII. RII overlay and immunoprecipitation assays demonstrate binding between Chd8-S and RIIα. Binding is abrogated upon dephosphorylation of RIIα. By immunofluorescence, we identified nuclear and perinuclear pools of Chd8 in HeLa cells and rat neonatal cardiomyocytes. We also show high levels of Chd8 mRNA in RNA extracted from post-natal rat hearts. These data add Chd8 to the short list of known nuclear AKAPs, and implicate a function for Chd8 in post-natal rat cardiac development." @default.
- W2085944730 created "2016-06-24" @default.
- W2085944730 creator A5048660573 @default.
- W2085944730 creator A5057954730 @default.
- W2085944730 creator A5071722839 @default.
- W2085944730 creator A5083140608 @default.
- W2085944730 creator A5087449906 @default.
- W2085944730 creator A5005533137 @default.
- W2085944730 date "2012-10-10" @default.
- W2085944730 modified "2023-09-27" @default.
- W2085944730 title "Chromodomain Helicase Binding Protein 8 (Chd8) Is a Novel A-Kinase Anchoring Protein Expressed during Rat Cardiac Development" @default.
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