Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085945766> ?p ?o ?g. }
- W2085945766 endingPage "1590" @default.
- W2085945766 startingPage "1571" @default.
- W2085945766 abstract "Aberrant angiogenesis has been observed in many solid tumors. The formation and metastases of tumors such as non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC) are very complex, often regulated by proangiogenic factors such as the vascular endothelial growth factor (VEGF) and other tyrosine kinases. The VEGFR, EGFR and mTOR pathways have played critical roles in controlling cell proliferation and angiogenesis. This paper reviews the mechanism and binding modes of recently approved tyrosine kinase inhibitors (TKIs), such as gefitinib, erlotinib, nilotinib, dasatinib, sunitinib, sorafenib, pazopanib, lapatinib, afinitor, and temsirolimus. We also cover the progresses of the recent development of tyrosine kinase inhibitors that are currently in the clinical trials at the phases I, II, and III, targeting the VEGFR, EGFR and/or mTOR pathways. Combination therapy intended to overcome drug resistance is also discussed. Recent TKI design based on the activation loop and the “DFG” conformation, is also discussed. Keywords: Vandetanib, cediranib, motesanib, axitinib, vatalanib, SU5416, BIBF1120, AEE788, tandutinib, linifanib, dovitinib, telatinib, regorafenib, E7080, XL880, brivanib, tivozanib, ponatinib" @default.
- W2085945766 created "2016-06-24" @default.
- W2085945766 creator A5032085118 @default.
- W2085945766 creator A5071858340 @default.
- W2085945766 date "2011-06-01" @default.
- W2085945766 modified "2023-10-16" @default.
- W2085945766 title "Recent Advances in Small Molecule Inhibitors of VEGFR and EGFR Signaling Pathways" @default.
- W2085945766 cites W119001892 @default.
- W2085945766 cites W145904191 @default.
- W2085945766 cites W1491779959 @default.
- W2085945766 cites W1502361999 @default.
- W2085945766 cites W1963714250 @default.
- W2085945766 cites W1963822859 @default.
- W2085945766 cites W1965727465 @default.
- W2085945766 cites W1967394241 @default.
- W2085945766 cites W1971328896 @default.
- W2085945766 cites W1971340381 @default.
- W2085945766 cites W1971699414 @default.
- W2085945766 cites W1973648602 @default.
- W2085945766 cites W1974938521 @default.
- W2085945766 cites W1983351797 @default.
- W2085945766 cites W1984492994 @default.
- W2085945766 cites W1987005540 @default.
- W2085945766 cites W1990524359 @default.
- W2085945766 cites W1992927350 @default.
- W2085945766 cites W1993675254 @default.
- W2085945766 cites W1998984120 @default.
- W2085945766 cites W2003717480 @default.
- W2085945766 cites W2003888937 @default.
- W2085945766 cites W2003973314 @default.
- W2085945766 cites W2004460690 @default.
- W2085945766 cites W2006202974 @default.
- W2085945766 cites W2007011751 @default.
- W2085945766 cites W2009334783 @default.
- W2085945766 cites W2010898909 @default.
- W2085945766 cites W2012238745 @default.
- W2085945766 cites W2012432365 @default.
- W2085945766 cites W2014771494 @default.
- W2085945766 cites W2015015957 @default.
- W2085945766 cites W2023231438 @default.
- W2085945766 cites W2027335142 @default.
- W2085945766 cites W2028892936 @default.
- W2085945766 cites W2029633750 @default.
- W2085945766 cites W2031498310 @default.
- W2085945766 cites W2033989981 @default.
- W2085945766 cites W2036218023 @default.
- W2085945766 cites W2036219324 @default.
- W2085945766 cites W2037819581 @default.
- W2085945766 cites W2041098552 @default.
- W2085945766 cites W2042382807 @default.
- W2085945766 cites W2044468942 @default.
- W2085945766 cites W2044565900 @default.
- W2085945766 cites W2045750704 @default.
- W2085945766 cites W2057718276 @default.
- W2085945766 cites W2062594120 @default.
- W2085945766 cites W2069698188 @default.
- W2085945766 cites W2069981843 @default.
- W2085945766 cites W2073059190 @default.
- W2085945766 cites W2074154821 @default.
- W2085945766 cites W2081269875 @default.
- W2085945766 cites W2082592896 @default.
- W2085945766 cites W2086409166 @default.
- W2085945766 cites W2086506462 @default.
- W2085945766 cites W2086978166 @default.
- W2085945766 cites W2089756110 @default.
- W2085945766 cites W2092606584 @default.
- W2085945766 cites W2092917054 @default.
- W2085945766 cites W2093613683 @default.
- W2085945766 cites W2096167489 @default.
- W2085945766 cites W2097373408 @default.
- W2085945766 cites W2098354753 @default.
- W2085945766 cites W2101635775 @default.
- W2085945766 cites W2103174300 @default.
- W2085945766 cites W2105261759 @default.
- W2085945766 cites W2105549867 @default.
- W2085945766 cites W2105984177 @default.
- W2085945766 cites W2106478689 @default.
- W2085945766 cites W2106932520 @default.
- W2085945766 cites W2109240520 @default.
- W2085945766 cites W2109833554 @default.
- W2085945766 cites W2110643890 @default.
- W2085945766 cites W2110648386 @default.
- W2085945766 cites W2110935327 @default.
- W2085945766 cites W2111109297 @default.
- W2085945766 cites W2111870457 @default.
- W2085945766 cites W2111879300 @default.
- W2085945766 cites W2114940128 @default.
- W2085945766 cites W2115078104 @default.
- W2085945766 cites W2118471405 @default.
- W2085945766 cites W2118559000 @default.
- W2085945766 cites W2119617160 @default.
- W2085945766 cites W2122210701 @default.
- W2085945766 cites W2122569550 @default.
- W2085945766 cites W2123769946 @default.
- W2085945766 cites W2124196948 @default.
- W2085945766 cites W2128307445 @default.
- W2085945766 cites W2129573915 @default.
- W2085945766 cites W2129851137 @default.