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• W2085963630 abstract "We examined the relationship between oxygen consumption (̇o2) and oxygen delivery (Do2) over a range of metabolic demand in two groups of children. We studied 15 children ofter cardiac surgery (plasma lactate levels <2.2 mmol/L, ̇o2<6 ml/min per kilogram, oxygen extraction ratio <25%); 8 were given transfusions with erythrocytes, 10 to 15 ml/kg, and 7 received adrenaline infusions (0.05 to 0.3 μg/kg per minute). Blood transfusions significantly increased Do2 (20.5±6.4 to 26.2±7.1 ml/min per kilogram; p<0.05) but did not alter ̇o2. Adrenaline increased Do2 (19.9±5.0 to 25.9±6.1 ml/min per kilogram; p<0.05) and ̇o2 (4.3±0.8 to 5.5±1.2 ml/min per kilogram; p<0.05), but the oxygen excretion ratio and the mixed venous oxygen, saturation were unchanged. We also measured ̇o2 and Doppler-derived Do2 in 25 normal children during exercise. The relationship during exercise is given by the following equation: ̇o2 index (in milliters per minute per kilogram)=0.88×Do2 index − 6.95. Adrenaline infusions, but not blood transfusions, increased ̇o2 and Do2 together. This effect may be due to increased demand, analogous to exercise, and probably does not represent improved perfusion. We also found significant measurement error in Do2 and spontaneous variation in ̇o2. We believe that the concept of supplydependent ̇o2 is based on a number of methodologic and measurement errors. It should not be used to justify potentially dangerous therapies in sick children. We examined the relationship between oxygen consumption (̇o2) and oxygen delivery (Do2) over a range of metabolic demand in two groups of children. We studied 15 children ofter cardiac surgery (plasma lactate levels <2.2 mmol/L, ̇o2<6 ml/min per kilogram, oxygen extraction ratio <25%); 8 were given transfusions with erythrocytes, 10 to 15 ml/kg, and 7 received adrenaline infusions (0.05 to 0.3 μg/kg per minute). Blood transfusions significantly increased Do2 (20.5±6.4 to 26.2±7.1 ml/min per kilogram; p<0.05) but did not alter ̇o2. Adrenaline increased Do2 (19.9±5.0 to 25.9±6.1 ml/min per kilogram; p<0.05) and ̇o2 (4.3±0.8 to 5.5±1.2 ml/min per kilogram; p<0.05), but the oxygen excretion ratio and the mixed venous oxygen, saturation were unchanged. We also measured ̇o2 and Doppler-derived Do2 in 25 normal children during exercise. The relationship during exercise is given by the following equation: ̇o2 index (in milliters per minute per kilogram)=0.88×Do2 index − 6.95. Adrenaline infusions, but not blood transfusions, increased ̇o2 and Do2 together. This effect may be due to increased demand, analogous to exercise, and probably does not represent improved perfusion. We also found significant measurement error in Do2 and spontaneous variation in ̇o2. We believe that the concept of supplydependent ̇o2 is based on a number of methodologic and measurement errors. It should not be used to justify potentially dangerous therapies in sick children." @default.
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• W2085963630 date "1993-08-01" @default.
• W2085963630 modified "2023-09-24" @default.
• W2085963630 title "Oxygen consumption-oxygen delivery relationship in children" @default.
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• W2085963630 doi "https://doi.org/10.1016/s0022-3476(05)81690-7" @default.
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