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- W2085965038 endingPage "3719" @default.
- W2085965038 startingPage "3719" @default.
- W2085965038 abstract "Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process. This process starts with a series of mutations in colonic epithelial cells, continues with their detachment from the large intestine, dissemination through the blood and/or lymphatic circulation, attachment to the hepatic sinusoids and interactions with the sinusoidal cells, such as sinusoidal endothelial cells, Kupffer cells, stellate cells and pit cells. The metastatic sequence terminates with colorectal cancer cell invasion, adaptation and colonisation of the hepatic parenchyma. All these events, termed the colorectal cancer invasion-metastasis cascade, include multiple molecular pathways, intercellular interactions and expression of a plethora of chemokines and growth factors, and adhesion molecules, such as the selectins, the integrins or the cadherins, as well as enzymes including matrix metalloproteinases. This review aims to present recent advances that provide insights into these cell-biological events and emphasizes those that may be amenable to therapeutic targeting." @default.
- W2085965038 created "2016-06-24" @default.
- W2085965038 creator A5050003973 @default.
- W2085965038 creator A5080348418 @default.
- W2085965038 creator A5090450624 @default.
- W2085965038 date "2014-01-01" @default.
- W2085965038 modified "2023-10-02" @default.
- W2085965038 title "Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance" @default.
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