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• W2085967369 abstract "Daldinia concentrica and Psathyrella efflorescens are two fungi used in African traditional medicine. In the present study, their extracts were evaluated for their steroid activities in estrogen- or androgen-dependent cell lines using as endpoints steroid-dependent transcriptional activity and cell proliferation. Treatment of human breast cancer MCF-7 cells with 15 or 30 μg/ml of Daldinia concentrica or Psathyrella efflorescens extracts in the absence of 17β-estradiol (E2) significantly increased the transcriptional activity of an estrogen receptor (ER)-dependent reporter gene, in the same range as E2. Similar data were obtained in gonadotrope cell line α-T3-1. All the effects were prevented by the pure estrogen antagonist, ICI 182,780. In the absence of steroid addition, the two extracts induced cell proliferation of ER-dependent MCF-7 and Ishikawa Var-I cell lines by approximately 100% of the E2 response. Combination treatments with E2 showed no competitive or additive effects in the two latter cell lines. Interestingly, the extracts had no androgen-like response in androgen receptor (AR)-positive and ER-negative MDA-MB231 cells, suggesting that fungi effects are estrogen specific and extracts are not toxic at used concentrations. Results provided evidence that Daldinia concentrica or Psathyrella efflorescens extracts induce estrogen-like effects in ER-positive cell lines, which could be responsible of the effects observed in vivo." @default.
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• W2085967369 date "2008-02-01" @default.
• W2085967369 modified "2023-10-16" @default.
• W2085967369 title "Estrogen effects of Daldinia concentrica and Psathyrella efflorescens extracts in vitro" @default.
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• W2085967369 doi "https://doi.org/10.1016/j.jep.2007.11.018" @default.
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