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- W2085970564 abstract "The rhizome of Atractylodes japonica Koidz. has been used traditionally for the treatment of water retention in the body and is known to have estrogen-like activity. In the present study, the protective effects of A. japonica root extract on the response of osteoblasts to oxidative stress were evaluated. Osteoblastic MC3T3-E1 cells were incubated with hydrogen peroxide and/or A. japonica root extract, and markers of osteoblast function and oxidative damage were examined. A. japonica root extract significantly (p < 0.05) increased cell survival, alkaline phosphatase activity, collagen and calcium deposition and decreased the production of receptor activator of nuclear factor-kB ligand (RANKL), protein carbonyl and malondialdehyde of osteoblastic MC3T3-E1 cells in the presence of hydrogen peroxide. These results demonstrate that A. japonica root can protect the cells from oxidative stress-induced toxicity and may have positive effects on skeletal structure. Copyright © 2009 John Wiley & Sons, Ltd." @default.
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- W2085970564 date "2009-05-13" @default.
- W2085970564 modified "2023-09-25" @default.
- W2085970564 title "<i>Atractylodes japonica</i> root extract protects osteoblastic MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation" @default.
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- W2085970564 doi "https://doi.org/10.1002/ptr.2813" @default.
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