FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085981618> ?p ?o ?g. }

• W2085981618 endingPage "1072" @default.
• W2085981618 startingPage "1060" @default.
• W2085981618 abstract "The vital importance of peroxisomal metabolism for regular function of the testis is stressed by the severe spermatogenesis defects induced by peroxisomal dysfunction. However, only sparse information is available on the role and enzyme composition of this organelle in distinct cell types of the testis. In the present study, we characterized the peroxisomal compartment in human and mouse testis in primary cultures of murine somatic cells (Sertoli, peritubular myoid, and Leydig cells) and in GFP-PTS1 transgenic mice with a variety of morphological and biochemical techniques. Formerly, peroxisomes were thought to be absent in late stages of spermatogenesis. However, our results obtained by detection of different peroxisomal marker proteins show the presence of these organelles in most cell types in the testis, except for mature spermatozoa. Furthermore, we demonstrate a strong heterogeneity of peroxisomal protein content in various cell types of the human and mouse testis and show marked differences in structure, abundance, and localization of these organelles in spermatids, depending on their maturation. Highest and selective enrichment of the peroxisomal lipid transporters (ABCD1 and ABCD3) as well as ACOX2, the key regulatory enzyme of the beta-oxidation pathway 2 for side chain oxidation of cholesterol, were found in Sertoli cells, whereas Leydig cells were enriched in catalase and ABCD2. Our results suggest a cell type-specific metabolic function of peroxisomes in the testis and point to an important role for peroxisomes in spermiogenesis and in the lipid metabolism of Sertoli cells." @default.
• W2085981618 created "2016-06-24" @default.
• W2085981618 creator A5064995734 @default.
• W2085981618 creator A5067768929 @default.
• W2085981618 creator A5081010628 @default.
• W2085981618 creator A5082351634 @default.
• W2085981618 creator A5082400216 @default.
• W2085981618 date "2007-12-01" @default.
• W2085981618 modified "2023-09-27" @default.
• W2085981618 title "Peroxisomes in Human and Mouse Testis: Differential Expression of Peroxisomal Proteins in Germ Cells and Distinct Somatic Cell Types of the Testis1" @default.
• W2085981618 cites W1577530156 @default.
• W2085981618 cites W179847816 @default.
• W2085981618 cites W187897128 @default.
• W2085981618 cites W1976909856 @default.
• W2085981618 cites W1980346504 @default.
• W2085981618 cites W1980347624 @default.
• W2085981618 cites W1980860909 @default.
• W2085981618 cites W1987774915 @default.
• W2085981618 cites W1992071762 @default.
• W2085981618 cites W1999190099 @default.
• W2085981618 cites W2021230596 @default.
• W2085981618 cites W2023098028 @default.
• W2085981618 cites W2035043331 @default.
• W2085981618 cites W2046275054 @default.
• W2085981618 cites W2046633980 @default.
• W2085981618 cites W2049230829 @default.
• W2085981618 cites W2056686949 @default.
• W2085981618 cites W2063861425 @default.
• W2085981618 cites W2079094773 @default.
• W2085981618 cites W2081337319 @default.
• W2085981618 cites W2085867188 @default.
• W2085981618 cites W2086448742 @default.
• W2085981618 cites W2092433700 @default.
• W2085981618 cites W2101641567 @default.
• W2085981618 cites W2105422846 @default.
• W2085981618 cites W2116753947 @default.
• W2085981618 cites W2123093073 @default.
• W2085981618 cites W2129208998 @default.
• W2085981618 cites W2130944611 @default.
• W2085981618 cites W2150885810 @default.
• W2085981618 cites W2154554555 @default.
• W2085981618 cites W2158056850 @default.
• W2085981618 cites W2160256928 @default.
• W2085981618 cites W2163041328 @default.
• W2085981618 cites W2163628182 @default.
• W2085981618 cites W348120869 @default.
• W2085981618 cites W4293247451 @default.
• W2085981618 doi "https://doi.org/10.1095/biolreprod.107.061242" @default.
• W2085981618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17881773" @default.
• W2085981618 hasPublicationYear "2007" @default.
• W2085981618 type Work @default.
• W2085981618 sameAs 2085981618 @default.
• W2085981618 citedByCount "59" @default.
• W2085981618 countsByYear W20859816182012 @default.
• W2085981618 countsByYear W20859816182013 @default.
• W2085981618 countsByYear W20859816182014 @default.
• W2085981618 countsByYear W20859816182015 @default.
• W2085981618 countsByYear W20859816182016 @default.
• W2085981618 countsByYear W20859816182017 @default.
• W2085981618 countsByYear W20859816182019 @default.
• W2085981618 countsByYear W20859816182020 @default.
• W2085981618 countsByYear W20859816182021 @default.
• W2085981618 countsByYear W20859816182022 @default.
• W2085981618 countsByYear W20859816182023 @default.
• W2085981618 crossrefType "journal-article" @default.
• W2085981618 hasAuthorship W2085981618A5064995734 @default.
• W2085981618 hasAuthorship W2085981618A5067768929 @default.
• W2085981618 hasAuthorship W2085981618A5081010628 @default.
• W2085981618 hasAuthorship W2085981618A5082351634 @default.
• W2085981618 hasAuthorship W2085981618A5082400216 @default.
• W2085981618 hasBestOaLocation W20859816181 @default.
• W2085981618 hasConcept C104317684 @default.
• W2085981618 hasConcept C123765429 @default.
• W2085981618 hasConcept C127078168 @default.
• W2085981618 hasConcept C134018914 @default.
• W2085981618 hasConcept C134305767 @default.
• W2085981618 hasConcept C1491633281 @default.
• W2085981618 hasConcept C168240541 @default.
• W2085981618 hasConcept C189014844 @default.
• W2085981618 hasConcept C2777736315 @default.
• W2085981618 hasConcept C2778575703 @default.
• W2085981618 hasConcept C2779122487 @default.
• W2085981618 hasConcept C2781068068 @default.
• W2085981618 hasConcept C55493867 @default.
• W2085981618 hasConcept C71315377 @default.
• W2085981618 hasConcept C86803240 @default.
• W2085981618 hasConcept C95444343 @default.
• W2085981618 hasConceptScore W2085981618C104317684 @default.
• W2085981618 hasConceptScore W2085981618C123765429 @default.
• W2085981618 hasConceptScore W2085981618C127078168 @default.
• W2085981618 hasConceptScore W2085981618C134018914 @default.
• W2085981618 hasConceptScore W2085981618C134305767 @default.
• W2085981618 hasConceptScore W2085981618C1491633281 @default.
• W2085981618 hasConceptScore W2085981618C168240541 @default.
• W2085981618 hasConceptScore W2085981618C189014844 @default.
• W2085981618 hasConceptScore W2085981618C2777736315 @default.
• W2085981618 hasConceptScore W2085981618C2778575703 @default.
• W2085981618 hasConceptScore W2085981618C2779122487 @default.

• next