FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085981708> ?p ?o ?g. }

• W2085981708 endingPage "7353" @default.
• W2085981708 startingPage "7349" @default.
• W2085981708 abstract "Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC(50) in the range of 0.10-9.87 μM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (IC(50)=0.10-0.56 μM). More importantly, 10f and several other compounds had comparable or stronger anti-inflammatory and analgesic activities, but better gastric tolerability in vivo, as compared with darbufelone mesilate and tenidap sodium. Therefore, our findings may aid in the design of new and safe anti-inflammatory reagents for the intervention of painful inflammatory diseases, such as rheumatoid arthritis at clinic." @default.
• W2085981708 created "2016-06-24" @default.
• W2085981708 creator A5008614366 @default.
• W2085981708 creator A5023794999 @default.
• W2085981708 creator A5026256993 @default.
• W2085981708 creator A5052894175 @default.
• W2085981708 creator A5069671658 @default.
• W2085981708 creator A5072793694 @default.
• W2085981708 creator A5075566791 @default.
• W2085981708 date "2010-12-01" @default.
• W2085981708 modified "2023-10-09" @default.
• W2085981708 title "Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors" @default.
• W2085981708 cites W1969855058 @default.
• W2085981708 cites W1972773419 @default.
• W2085981708 cites W1980832959 @default.
• W2085981708 cites W1981816788 @default.
• W2085981708 cites W1982845798 @default.
• W2085981708 cites W1984233793 @default.
• W2085981708 cites W2001162433 @default.
• W2085981708 cites W2002138692 @default.
• W2085981708 cites W2007187686 @default.
• W2085981708 cites W2009422790 @default.
• W2085981708 cites W2010068598 @default.
• W2085981708 cites W2012801178 @default.
• W2085981708 cites W2017203125 @default.
• W2085981708 cites W2047854358 @default.
• W2085981708 cites W2076667186 @default.
• W2085981708 cites W2078259729 @default.
• W2085981708 cites W2086418186 @default.
• W2085981708 cites W2108687569 @default.
• W2085981708 cites W2109557300 @default.
• W2085981708 cites W2128680329 @default.
• W2085981708 cites W2129761607 @default.
• W2085981708 cites W2158131645 @default.
• W2085981708 cites W2317663711 @default.
• W2085981708 cites W2318626829 @default.
• W2085981708 cites W4244067219 @default.
• W2085981708 cites W45638005 @default.
• W2085981708 doi "https://doi.org/10.1016/j.bmcl.2010.10.056" @default.
• W2085981708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21055929" @default.
• W2085981708 hasPublicationYear "2010" @default.
• W2085981708 type Work @default.
• W2085981708 sameAs 2085981708 @default.
• W2085981708 citedByCount "46" @default.
• W2085981708 countsByYear W20859817082012 @default.
• W2085981708 countsByYear W20859817082013 @default.
• W2085981708 countsByYear W20859817082014 @default.
• W2085981708 countsByYear W20859817082015 @default.
• W2085981708 countsByYear W20859817082016 @default.
• W2085981708 countsByYear W20859817082017 @default.
• W2085981708 countsByYear W20859817082018 @default.
• W2085981708 countsByYear W20859817082019 @default.
• W2085981708 countsByYear W20859817082020 @default.
• W2085981708 countsByYear W20859817082021 @default.
• W2085981708 countsByYear W20859817082022 @default.
• W2085981708 countsByYear W20859817082023 @default.
• W2085981708 crossrefType "journal-article" @default.
• W2085981708 hasAuthorship W2085981708A5008614366 @default.
• W2085981708 hasAuthorship W2085981708A5023794999 @default.
• W2085981708 hasAuthorship W2085981708A5026256993 @default.
• W2085981708 hasAuthorship W2085981708A5052894175 @default.
• W2085981708 hasAuthorship W2085981708A5069671658 @default.
• W2085981708 hasAuthorship W2085981708A5072793694 @default.
• W2085981708 hasAuthorship W2085981708A5075566791 @default.
• W2085981708 hasConcept C114373084 @default.
• W2085981708 hasConcept C126322002 @default.
• W2085981708 hasConcept C150903083 @default.
• W2085981708 hasConcept C155647269 @default.
• W2085981708 hasConcept C178790620 @default.
• W2085981708 hasConcept C181199279 @default.
• W2085981708 hasConcept C185592680 @default.
• W2085981708 hasConcept C197934379 @default.
• W2085981708 hasConcept C202751555 @default.
• W2085981708 hasConcept C207001950 @default.
• W2085981708 hasConcept C21951064 @default.
• W2085981708 hasConcept C2777454769 @default.
• W2085981708 hasConcept C2777575956 @default.
• W2085981708 hasConcept C2778375690 @default.
• W2085981708 hasConcept C2780820201 @default.
• W2085981708 hasConcept C40875361 @default.
• W2085981708 hasConcept C55493867 @default.
• W2085981708 hasConcept C71240020 @default.
• W2085981708 hasConcept C71924100 @default.
• W2085981708 hasConcept C86803240 @default.
• W2085981708 hasConcept C98274493 @default.
• W2085981708 hasConceptScore W2085981708C114373084 @default.
• W2085981708 hasConceptScore W2085981708C126322002 @default.
• W2085981708 hasConceptScore W2085981708C150903083 @default.
• W2085981708 hasConceptScore W2085981708C155647269 @default.
• W2085981708 hasConceptScore W2085981708C178790620 @default.
• W2085981708 hasConceptScore W2085981708C181199279 @default.
• W2085981708 hasConceptScore W2085981708C185592680 @default.
• W2085981708 hasConceptScore W2085981708C197934379 @default.
• W2085981708 hasConceptScore W2085981708C202751555 @default.
• W2085981708 hasConceptScore W2085981708C207001950 @default.
• W2085981708 hasConceptScore W2085981708C21951064 @default.
• W2085981708 hasConceptScore W2085981708C2777454769 @default.
• W2085981708 hasConceptScore W2085981708C2777575956 @default.

• next