Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085985952> ?p ?o ?g. }
- W2085985952 endingPage "15014" @default.
- W2085985952 startingPage "15006" @default.
- W2085985952 abstract "Wnt/β-catenin signaling plays key roles in embryonic development and tissue homeostasis. Dapper3/Dact3, one of the three members of the Dapper gene family, is transcriptionally repressed in colorectal cancer and may function as a negative regulator of Wnt/β-catenin signaling. To investigate its physiological functions, we generated a mouse strain harboring conditional null alleles of Dapper3 (Dapper3(flox/flox)), and homozygous Dapper3-deficient (Dapper3(-/-)) mice were produced after crossing with EIIa-cre transgenic mice. We found that Dapper3 is not essential for mouse embryogenesis, postnatal survival, and reproduction. However, adult Dapper3(-/-) mice exhibited a mild reduction in body weight compared with their wild-type littermates, suggesting a functional role of Dapper3 in postnatal growth. To investigate the role of Dapper3 in renal fibrosis, we employed the unilateral ureteral obstruction model. Dapper3 mRNA expression was up-regulated in kidney after unilateral ureteral obstruction. Loss of the Dapper3 gene enhanced myofibroblast activation and extracellular matrix overproduction in the obstructed kidney. Moreover, this aggravated fibrotic phenotype was accompanied with accumulation of Dishevelled2 and β-catenin proteins and activation of Wnt-targeted fibrotic genes. In primary renal tubular cells, Dapper3 inhibits Wnt-induced epithelial-to-mesenchymal transition. Consistently, Dapper3 interacted with and down-regulated Dishevelled2 protein and attenuated the Wnt-responsive Topflash reporter expression. These findings together suggest that Dapper3 antagonizes the fibrotic actions of Wnt signaling in kidney." @default.
- W2085985952 created "2016-06-24" @default.
- W2085985952 creator A5001080717 @default.
- W2085985952 creator A5015608874 @default.
- W2085985952 creator A5017774638 @default.
- W2085985952 creator A5021216873 @default.
- W2085985952 creator A5031295186 @default.
- W2085985952 creator A5037794174 @default.
- W2085985952 creator A5058223300 @default.
- W2085985952 creator A5058814917 @default.
- W2085985952 creator A5070019572 @default.
- W2085985952 creator A5091655194 @default.
- W2085985952 date "2013-05-01" @default.
- W2085985952 modified "2023-09-26" @default.
- W2085985952 title "Disruption of the Dapper3 Gene Aggravates Ureteral Obstruction-mediated Renal Fibrosis by Amplifying Wnt/β-catenin Signaling" @default.
- W2085985952 cites W1495670272 @default.
- W2085985952 cites W1534431990 @default.
- W2085985952 cites W1987979328 @default.
- W2085985952 cites W1991527612 @default.
- W2085985952 cites W1997582300 @default.
- W2085985952 cites W1999145232 @default.
- W2085985952 cites W2001943261 @default.
- W2085985952 cites W2005440429 @default.
- W2085985952 cites W2006419043 @default.
- W2085985952 cites W2008770488 @default.
- W2085985952 cites W2009295603 @default.
- W2085985952 cites W2025744983 @default.
- W2085985952 cites W2031760316 @default.
- W2085985952 cites W2033457930 @default.
- W2085985952 cites W2034662853 @default.
- W2085985952 cites W2042063432 @default.
- W2085985952 cites W2046953617 @default.
- W2085985952 cites W2049533449 @default.
- W2085985952 cites W2067976936 @default.
- W2085985952 cites W2071497196 @default.
- W2085985952 cites W2073606881 @default.
- W2085985952 cites W2080347068 @default.
- W2085985952 cites W2083943004 @default.
- W2085985952 cites W2094637604 @default.
- W2085985952 cites W2095202492 @default.
- W2085985952 cites W2101766543 @default.
- W2085985952 cites W2102864788 @default.
- W2085985952 cites W2109932915 @default.
- W2085985952 cites W2127530565 @default.
- W2085985952 cites W2132100007 @default.
- W2085985952 cites W2133289216 @default.
- W2085985952 cites W2143227567 @default.
- W2085985952 cites W2144197789 @default.
- W2085985952 cites W2149879690 @default.
- W2085985952 cites W2151582261 @default.
- W2085985952 cites W2156490871 @default.
- W2085985952 cites W2169453638 @default.
- W2085985952 cites W2767091614 @default.
- W2085985952 doi "https://doi.org/10.1074/jbc.m113.458448" @default.
- W2085985952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3663521" @default.
- W2085985952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23580654" @default.
- W2085985952 hasPublicationYear "2013" @default.
- W2085985952 type Work @default.
- W2085985952 sameAs 2085985952 @default.
- W2085985952 citedByCount "21" @default.
- W2085985952 countsByYear W20859859522013 @default.
- W2085985952 countsByYear W20859859522014 @default.
- W2085985952 countsByYear W20859859522015 @default.
- W2085985952 countsByYear W20859859522016 @default.
- W2085985952 countsByYear W20859859522017 @default.
- W2085985952 countsByYear W20859859522019 @default.
- W2085985952 countsByYear W20859859522020 @default.
- W2085985952 countsByYear W20859859522022 @default.
- W2085985952 countsByYear W20859859522023 @default.
- W2085985952 crossrefType "journal-article" @default.
- W2085985952 hasAuthorship W2085985952A5001080717 @default.
- W2085985952 hasAuthorship W2085985952A5015608874 @default.
- W2085985952 hasAuthorship W2085985952A5017774638 @default.
- W2085985952 hasAuthorship W2085985952A5021216873 @default.
- W2085985952 hasAuthorship W2085985952A5031295186 @default.
- W2085985952 hasAuthorship W2085985952A5037794174 @default.
- W2085985952 hasAuthorship W2085985952A5058223300 @default.
- W2085985952 hasAuthorship W2085985952A5058814917 @default.
- W2085985952 hasAuthorship W2085985952A5070019572 @default.
- W2085985952 hasAuthorship W2085985952A5091655194 @default.
- W2085985952 hasBestOaLocation W20859859521 @default.
- W2085985952 hasConcept C104317684 @default.
- W2085985952 hasConcept C126322002 @default.
- W2085985952 hasConcept C134018914 @default.
- W2085985952 hasConcept C137620995 @default.
- W2085985952 hasConcept C145103041 @default.
- W2085985952 hasConcept C207865475 @default.
- W2085985952 hasConcept C2777632694 @default.
- W2085985952 hasConcept C2779324961 @default.
- W2085985952 hasConcept C2780091579 @default.
- W2085985952 hasConcept C2780559512 @default.
- W2085985952 hasConcept C2781430442 @default.
- W2085985952 hasConcept C502942594 @default.
- W2085985952 hasConcept C54355233 @default.
- W2085985952 hasConcept C62478195 @default.
- W2085985952 hasConcept C71924100 @default.
- W2085985952 hasConcept C86803240 @default.
- W2085985952 hasConcept C95444343 @default.