Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085988098> ?p ?o ?g. }
- W2085988098 endingPage "153" @default.
- W2085988098 startingPage "129" @default.
- W2085988098 abstract "Considerable work still needs to be done to understand more fully the basic processes going on inside the non-photosynthetic plastid organelle of Plasmodium spp., the causative agent of malaria. Following an explosion of genomic and transcriptional information in recent years, research workers are still analysing these data looking for new material relevant to the plastid. Several metabolic and housekeeping functions based on bacterial biochemistry have been elucidated and this has given impetus to finding lead inhibitors based on established anti-microbials. Structural investigations of plastid-associated enzymes identified as potential targets have begun. This review gives a perspective on the research to date and hopes to emphasize that a practical outcome for the clinic should be an important focus of future efforts. Malaria parasites have become resistant to front-line anti-malarials that are widely used and were formerly dependable. This has become a worrying problem in many regions where malaria is endemic. The time lag between hunting for new inhibitors and their application as pharmaceuticals is so long and costly that a steady stream of new ventures has to be undertaken to give a reasonable chance of finding affordable and appropriate anti-malarials for the future. Attempts to find inhibitors of the plastid organelle of the malaria parasite should be intensified in such programmes." @default.
- W2085988098 created "2016-06-24" @default.
- W2085988098 creator A5057053588 @default.
- W2085988098 date "2005-02-01" @default.
- W2085988098 modified "2023-09-26" @default.
- W2085988098 title "Parasite plastids: approaching the endgame" @default.
- W2085988098 cites W1499640952 @default.
- W2085988098 cites W1512031035 @default.
- W2085988098 cites W1512118519 @default.
- W2085988098 cites W1512387447 @default.
- W2085988098 cites W1512565037 @default.
- W2085988098 cites W1515235319 @default.
- W2085988098 cites W1520265262 @default.
- W2085988098 cites W1551787983 @default.
- W2085988098 cites W1551802448 @default.
- W2085988098 cites W1591479113 @default.
- W2085988098 cites W1617412318 @default.
- W2085988098 cites W1653464985 @default.
- W2085988098 cites W1762630411 @default.
- W2085988098 cites W1830555632 @default.
- W2085988098 cites W1834249524 @default.
- W2085988098 cites W195201687 @default.
- W2085988098 cites W1960048856 @default.
- W2085988098 cites W1964343317 @default.
- W2085988098 cites W1964653010 @default.
- W2085988098 cites W1964697533 @default.
- W2085988098 cites W1965214672 @default.
- W2085988098 cites W1965332062 @default.
- W2085988098 cites W1971594953 @default.
- W2085988098 cites W1972499484 @default.
- W2085988098 cites W1975627947 @default.
- W2085988098 cites W1975676078 @default.
- W2085988098 cites W1976826704 @default.
- W2085988098 cites W1978663690 @default.
- W2085988098 cites W1986178963 @default.
- W2085988098 cites W1990286749 @default.
- W2085988098 cites W1990617810 @default.
- W2085988098 cites W1991236015 @default.
- W2085988098 cites W1991499538 @default.
- W2085988098 cites W1991579147 @default.
- W2085988098 cites W1992028223 @default.
- W2085988098 cites W1992233431 @default.
- W2085988098 cites W1993127355 @default.
- W2085988098 cites W1993538003 @default.
- W2085988098 cites W1993798031 @default.
- W2085988098 cites W1993818604 @default.
- W2085988098 cites W1994816147 @default.
- W2085988098 cites W1995734836 @default.
- W2085988098 cites W1995950751 @default.
- W2085988098 cites W1998121672 @default.
- W2085988098 cites W1998142761 @default.
- W2085988098 cites W1998433151 @default.
- W2085988098 cites W1998551227 @default.
- W2085988098 cites W1998567654 @default.
- W2085988098 cites W1999325366 @default.
- W2085988098 cites W1999439874 @default.
- W2085988098 cites W2000959843 @default.
- W2085988098 cites W2001437131 @default.
- W2085988098 cites W2001975832 @default.
- W2085988098 cites W2002079583 @default.
- W2085988098 cites W2002258545 @default.
- W2085988098 cites W2004901557 @default.
- W2085988098 cites W2004917621 @default.
- W2085988098 cites W2005305016 @default.
- W2085988098 cites W2006472037 @default.
- W2085988098 cites W2007826649 @default.
- W2085988098 cites W2009690860 @default.
- W2085988098 cites W2011584519 @default.
- W2085988098 cites W2016636420 @default.
- W2085988098 cites W2017136904 @default.
- W2085988098 cites W2019851585 @default.
- W2085988098 cites W2019995806 @default.
- W2085988098 cites W2022491296 @default.
- W2085988098 cites W2024249766 @default.
- W2085988098 cites W2026058848 @default.
- W2085988098 cites W2028280256 @default.
- W2085988098 cites W2030773468 @default.
- W2085988098 cites W2031254653 @default.
- W2085988098 cites W2031389000 @default.
- W2085988098 cites W2032009590 @default.
- W2085988098 cites W2032392349 @default.
- W2085988098 cites W2037074028 @default.
- W2085988098 cites W2037365757 @default.
- W2085988098 cites W2038219691 @default.
- W2085988098 cites W2038914330 @default.
- W2085988098 cites W2039943732 @default.
- W2085988098 cites W2040318221 @default.
- W2085988098 cites W2040781918 @default.
- W2085988098 cites W2041720520 @default.
- W2085988098 cites W2041805028 @default.
- W2085988098 cites W2049679577 @default.
- W2085988098 cites W2050580351 @default.
- W2085988098 cites W2051317564 @default.
- W2085988098 cites W2051452286 @default.
- W2085988098 cites W2052823571 @default.
- W2085988098 cites W2054627528 @default.
- W2085988098 cites W2056252656 @default.
- W2085988098 cites W2056365640 @default.