FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085989095> ?p ?o ?g. }

• W2085989095 abstract "Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FLDuring the course of experiments to determine the effects of elevated body temperature on anti-tumor immune responses, we unexpectedly observed that in control animals bearing tumors and maintained under standard room temperatures (IACUC-compliant, 21-23°C), the core temperature actually began to fall significantly as the tumors grew larger. Moreover, using thermal preference analyses, we found that animals bearing tumors exhibit considerable heat-seeking behavior. In an attempt to keep body temperature within the normal range (∼37°C), we began to house tumor bearing mice in a warmer environment (i.e., 28-30°C) considered to be the thermoneutral temperature for mice, as apposed to IACUC compliant temperatures which are considered mildly hypothermic for mice. Decisions that have resulted in the mildly cooler environmental temperature required in animal colonies have been generally based upon optimizing air-handling capacity of fumes and the thermal comfort of personnel rather than the optimal thermal comfort of animals (hence the requirements for multiple mice per cage to allow for huddling). When we analyzed tumor growth under thermoneutral conditions, syngeneic tumor growth was significantly delayed in animals maintained at 28-30°C compared to tumor growth in animals maintained at 21-23 oC. If the same comparison is made using SCID mice, no difference in tumor growth rate is observed. More specifically, BALB/c, C57BL/6 and SCID mice were housed in either standard room temperature (RT = 21-23°C) or in a warmer ambient temperature (WR = 28-30°C). Mice were then implanted with a syngeneic tumor (CT26 for BALB/c and SCID; B16.F10 for C57BL/6) subcutaneously and tumor growth was monitored. Tumor growth in C57BL/6 and BALB/c mice was inhibited when mice were housed in the warmer ambient temperature compared to animals maintained in standard room temperature. There was no difference in CT26 tumor growth in SCID mice. This finding suggested that the T cell-dependent anti-tumor immune response may be at least partly responsible for enhanced tumor growth control under conditions of warmer ambient temperature. Results of depletion studies in C57BL/6 mice bearing B16.F10 tumors, showed that both CD4+ and CD8+ T cells were required for inhibition of tumor growth in the warmer ambient temperature. In BALB/c mice bearing CT26 tumors, only CD8+ T cells were required to inhibit tumor growth. These findings suggest that the natural anti-tumor immune response exhibited by mice housed in standard colony conditions is sub-optimal and can be improved simply by housing mice under thermoneutral conditions. T cell dependent anti-tumor immunity appears to be at least one immune mechanism which is improved when animals are not cold stressed. Supported by NIH R01 CA 135368.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 790. doi:10.1158/1538-7445.AM2011-790" @default.
• W2085989095 created "2016-06-24" @default.
• W2085989095 creator A5008782074 @default.
• W2085989095 creator A5013462761 @default.
• W2085989095 creator A5029344793 @default.
• W2085989095 creator A5061211936 @default.
• W2085989095 date "2011-04-15" @default.
• W2085989095 modified "2023-09-26" @default.
• W2085989095 title "Abstract 790: Are laboratory mice too cold to mount effective anti-tumor immune responses" @default.
• W2085989095 doi "https://doi.org/10.1158/1538-7445.am2011-790" @default.
• W2085989095 hasPublicationYear "2011" @default.
• W2085989095 type Work @default.
• W2085989095 sameAs 2085989095 @default.
• W2085989095 citedByCount "0" @default.
• W2085989095 crossrefType "proceedings-article" @default.
• W2085989095 hasAuthorship W2085989095A5008782074 @default.
• W2085989095 hasAuthorship W2085989095A5013462761 @default.
• W2085989095 hasAuthorship W2085989095A5029344793 @default.
• W2085989095 hasAuthorship W2085989095A5061211936 @default.
• W2085989095 hasConcept C140793950 @default.
• W2085989095 hasConcept C203014093 @default.
• W2085989095 hasConcept C42407357 @default.
• W2085989095 hasConcept C71924100 @default.
• W2085989095 hasConcept C86803240 @default.
• W2085989095 hasConcept C8891405 @default.
• W2085989095 hasConceptScore W2085989095C140793950 @default.
• W2085989095 hasConceptScore W2085989095C203014093 @default.
• W2085989095 hasConceptScore W2085989095C42407357 @default.
• W2085989095 hasConceptScore W2085989095C71924100 @default.
• W2085989095 hasConceptScore W2085989095C86803240 @default.
• W2085989095 hasConceptScore W2085989095C8891405 @default.
• W2085989095 hasLocation W20859890951 @default.
• W2085989095 hasOpenAccess W2085989095 @default.
• W2085989095 hasPrimaryLocation W20859890951 @default.
• W2085989095 hasRelatedWork W1503498327 @default.
• W2085989095 hasRelatedWork W1698089433 @default.
• W2085989095 hasRelatedWork W1974735062 @default.
• W2085989095 hasRelatedWork W1982811855 @default.
• W2085989095 hasRelatedWork W2038073433 @default.
• W2085989095 hasRelatedWork W207737577 @default.
• W2085989095 hasRelatedWork W2087988219 @default.
• W2085989095 hasRelatedWork W2099162892 @default.
• W2085989095 hasRelatedWork W2151510773 @default.
• W2085989095 hasRelatedWork W2322237663 @default.
• W2085989095 hasRelatedWork W2334848796 @default.
• W2085989095 hasRelatedWork W2346896583 @default.
• W2085989095 hasRelatedWork W2364511106 @default.
• W2085989095 hasRelatedWork W2389418040 @default.
• W2085989095 hasRelatedWork W2394911061 @default.
• W2085989095 hasRelatedWork W2415722414 @default.
• W2085989095 hasRelatedWork W2417731403 @default.
• W2085989095 hasRelatedWork W2604927443 @default.
• W2085989095 hasRelatedWork W3181523802 @default.
• W2085989095 hasRelatedWork W2188712146 @default.
• W2085989095 isParatext "false" @default.
• W2085989095 isRetracted "false" @default.
• W2085989095 magId "2085989095" @default.
• W2085989095 workType "article" @default.