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• W2085992816 abstract "In this study, a series of aspartate based dendrimers with different cores were synthesized in a convergent approach and well characterized by NMR and MS techniques. The aqueous solubility of the model drugs (L-Histidine, Naproxen, Methotrexate) was measured in the presence of this kind of dendrimers at room temperature in PBS buffers at pH 6, 7 and 8. Results clearly confirmed that the solubility enhancement was due to presence of dendrimers at different pH compared to their corresponding aqueous solubility at different pH. The results indicated that the aspartate based dendrimers could be considered as an effective supplement of PAMAM dendrimers in solubility enhancement and drug delivery. The surface groups played an important role in dendrimer-mediated solubility enhancement." @default.
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• W2085992816 date "2010-06-01" @default.
• W2085992816 modified "2023-10-18" @default.
• W2085992816 title "Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs" @default.
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• W2085992816 doi "https://doi.org/10.1016/j.ejmech.2010.01.069" @default.
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