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• W2085997002 abstract "Abstract Delayed-type hypersensitivity (DTH) responses to the idiotype (Id) of the isologous immunoglobulins (Igs) could be demonstrated in Balb/c mice immunized with M315 or its Fv fragment (Fv-315) in complete Freund's adjuvant (CFA) by challenging primed animals in the ear with aqueous M315. Normal Balb/c mice receiving soluble M315 or Fv-315 seven days prior to sensitization with M315 showed marked suppression of the DTH specific to the Id but not to the other Id. The suppression has been shown to be attributed to active suppression and involves the generation of suppressor T-cells, Thus, the suppression induced with a single i.v. injection of free Fv-315 solution was transferable with both spleen cells and thymocytes from mice pretreated with Fv-315. These suppressor cells are T-cells since their ability to suppress DTH is completely abrogated by treatment with anti-Thy 1.2 serum and complement." @default.
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• W2085997002 date "1981-03-01" @default.
• W2085997002 modified "2023-09-28" @default.
• W2085997002 title "Induction of idiotype-specific suppressor T-cells with soluble Fv fragment" @default.
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• W2085997002 doi "https://doi.org/10.1016/0165-2478(81)90026-2" @default.
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