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• W2085999208 abstract "The present study evaluated the costimulatory effects of complement receptor type 3 (CR3) and Fc receptor for IgG (FcγR) on superoxide production and intracellular signal transduction in bovine neutrophils. Stimulation with opsonized zymosan (OPZ) and heat-aggregated bovine IgG (Agg-IgG) resulted in much greater superoxide production and chemiluminescent (CL) responses in normal neutrophils compared with those stimulated with OPZ or Agg-IgG only. Superoxide production and CL response were closely associated with the stimulant-induced rise of the intracellular calcium ([Ca2+]i) concentration, amount of tyrosine phosphorylated 100 kDa protein, and activation of p38 mitogen-activated protein kinase (p38 MAPK). No costimulatory effect was found for these receptors on superoxide production in CR3-deficient neutrophils. Costimulation of CR3 and FcγR on bovine neutrophils leads to enhancement of superoxide production and their signaling pathways and appears to be associated with enhancement of neutrophil functions." @default.
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• W2085999208 date "2007-01-01" @default.
• W2085999208 modified "2023-09-26" @default.
• W2085999208 title "Costimulatory Effects of Complement Receptor Type 3 and Fc Receptor for IgG (Fc.GAMMA.R) on Superoxide Production and Signal Transduction in Bovine Neutrophils" @default.
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• W2085999208 doi "https://doi.org/10.1292/jvms.69.993" @default.
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