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- W2086013450 abstract "Cholecystokinin-octapeptide (CCK-OP) is a potent and specific suppressor of feeding in sheep. Continuous injections into the lateral cerebral ventricles in 2-hr fasted sheep of as little as 0.01 pmoles/min significantly decreased feed intake for up to 60 min, and doses of 0.638 and 2.55 pmoles/min completely suppressed feeding during the entire 3-hr injection. Since continuous intravenous injection of 2.55 pmoles/min did not affect feed intake, CCK-OP's effect on feeding is apparently mediated by the CNS. Several factors can limit feed intake independently of a primary effect on satiety, but CCK-OP-induced suppression of feed intake was due neither to decreased water intake in water-deprived sheep nor to elevated body temperature. The CNS can affect rumen function which in turn can alter feeding behavior. We also found that CCK-OP elicited changes in contraction amplitude, even in sheep without feed, similar to those which occurred with feeding during sCSF control injections. We hypothesize that CCK-OP is released in the CNS by meal-related signals from the periphery, and that it then acts in the brain to produce satiety and possibly to mediate other changes that occur during a meal." @default.
- W2086013450 created "2016-06-24" @default.
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- W2086013450 date "1980-05-01" @default.
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- W2086013450 title "CCK-octapeptide injected in CSF and changes in feed intake and rumen motility" @default.
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- W2086013450 doi "https://doi.org/10.1016/0031-9384(80)90154-7" @default.
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