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- W2086013684 endingPage "52" @default.
- W2086013684 startingPage "1" @default.
- W2086013684 abstract "The principal dopamine (DA) receptors mediating the antiparkinson effects of levodopa are D1 and D2, which are anatomically and functionally segregated. We hypothesize that DA receptor-mediated effects are critical for the development of treatment-related fluctuations in Parkinson's disease (PD). We suggest that two sequential processes occur to permit the emergence of the so-called short duration response and dyskinesias: (1) functional uncoupling of D1 and D2 receptor-mediated effects with shift to the left of the dose-response curve; and, (2) sensitization of the D1-mediated striatal output due to repetitive, primarily D1 receptor stimulation by DA. These mechanisms result in excessive, pathological inhibition of basal ganglia output neurons in the GPi producing dyskinesias and the short duration response." @default.
- W2086013684 created "2016-06-24" @default.
- W2086013684 creator A5029576118 @default.
- W2086013684 creator A5042163606 @default.
- W2086013684 date "1989-01-01" @default.
- W2086013684 modified "2023-10-16" @default.
- W2086013684 title "Drugs acting on brain dopamine receptors: A conceptual re-evaluation five years after the first selective D-1 antagonist" @default.
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