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• W2086022249 endingPage "C1014" @default.
• W2086022249 startingPage "C1003" @default.
• W2086022249 abstract "Kv4/K channel interacting protein (KChIP) potassium channels are a major class of rapidly inactivating K(+) channels in neurons and cardiac muscle. Modulation of Kv4/KChIP channels by polyunsaturated fatty acids (PUFAs) is important in the regulation of cellular excitability and the induction of activity-dependent synaptic plasticity. Using the Xenopus laevis oocyte expression system, we studied the inhibition by PUFAs of the peak outward K(+) current and the accompanying increase in the rate of current inactivation of rKv4.2/rKChIP1b. Inhibitory effects do not depend on KChIP coexpression since Kv4.2 channels lacking an NH(2)-terminal KChIP association region were substantially inhibited by PUFAs and showed strong kinetic modulation. PUFAs accelerated both the fast and slow time constants that describe the kinetics of Kv4/KChIP inactivation. The time course of entry into closed inactivated states was facilitated by PUFAs, but steady-state inactivation and recovery from inactivation were unaltered. PUFA inhibition of Kv4/KChIP current was not use dependent. The concentration-response relationship for arachidonic acid (AA) inhibition of Kv4/KChIP channels mimicked that for activation of TRAAK channels. Internal serum albumin largely prevents the inhibitory effects of externally applied AA, and the membrane-impermeant AA-CoA is inactive when applied externally. Overall, our data suggest that PUFAs inhibit Kv4/KChIP channels by facilitating inactivation from open and closed gating states and that access of the fatty acid to the internal leaflet of the membrane is important. These results improve our understanding of the mechanisms for the inhibitory effects of PUFAs on Kv4/KChIP channel function." @default.
• W2086022249 created "2016-06-24" @default.
• W2086022249 creator A5002398069 @default.
• W2086022249 creator A5048024747 @default.
• W2086022249 creator A5050642679 @default.
• W2086022249 creator A5056689653 @default.
• W2086022249 date "2009-05-01" @default.
• W2086022249 modified "2023-09-23" @default.
• W2086022249 title "Inhibitory effects of polyunsaturated fatty acids on Kv4/KChIP potassium channels" @default.
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• W2086022249 doi "https://doi.org/10.1152/ajpcell.00474.2008" @default.
• W2086022249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2681380" @default.
• W2086022249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19261906" @default.
• W2086022249 hasPublicationYear "2009" @default.
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