FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086032237> ?p ?o ?g. }

• W2086032237 abstract "1. The effect of R75231, an inhibitor of purine nucleoside transport, were examined on ischaemic arrhythmias in anaesthetized pigs. 2. In closed chest pigs (n = 4), R75231 exerted a moderate dose-dependent decrease in mean arterial blood pressure (from 97 +/- 4 mmHg to 95 +/- 4, 90 +/- 1 and 83 +/- 2 mmHg at 25, 50 and 100 micrograms kg-1 respectively) and produced a dose-related shift to the left of the blood pressure dose-response curve to intravenous bolus doses of adenosine. The degree of inhibition of adenosine uptake by R75231, assessed ex vivo in erythrocyte suspensions, was 43 +/- 5%, 64 +/- 13 and 114 +/- 15% at doses of 25, 50 and 100 micrograms kg-1 respectively. 3. In open chest pigs, intravenous injection of R75231 (50 micrograms kg-1; n = 6 and 100 micrograms kg-1; n = 10) induced a dose-related decrease in both systolic and diastolic arterial blood pressure which was more marked than in closed-chest pigs (mean pressure 86 +/- 4 to 70 +/- 2 mmHg and 88 +/- 6 to 60 +/- 6 mmHg with 50 and 100 micrograms kg-1 respectively), without affecting heart rate or myocardial contractility. Coronary artery occlusion in these pigs caused a secondary decrease in blood pressure. This was not observed in controls (n = 10). The lower dose of R75231 did not exert any antifibrillatory effects, whereas the higher dose significantly reduced the incidence of ventricular fibrillation, from 80% in control pigs to 30%. Neither dose modified the incidence of ventricular tachycardia (33% and 40% with 50 and 100 microg kg-1 respectively, compared to 30% in controls) or had any effect on the total number of ventricular ectopic beats (85 +/- 47 and 130 +/- 31 vs 110 +/- 19 in controls). R75231, at a dose of 100 microg kg-1, also attenuated the ischaemia-induced shortening of QRS-interval, but neither dose modified the ST-segment depression seen following occlusion.4. These results show that the nucleoside transport inhibitor, R75231, exerts an antifibrillatory effect ina model of severe myocardial ischaemia in a dose which completely inhibits adenosine uptake ex vivo.However, while this agent has minimal haemodynamic effects in closed chest animals, the reduction in blood pressure induced by R75231 in open-chest pigs cannot be excluded as a possible contributory mechanism of the antiarrhythmic effects of this drug." @default.
• W2086032237 created "2016-06-24" @default.
• W2086032237 creator A5021736284 @default.
• W2086032237 creator A5031824382 @default.
• W2086032237 creator A5083939564 @default.
• W2086032237 date "1993-06-01" @default.
• W2086032237 modified "2023-10-18" @default.
• W2086032237 title "The antiarrhythmic effects of the nucleoside transporter inhibitor, R75231, in anaesthetized pigs" @default.
• W2086032237 cites W1941804339 @default.
• W2086032237 cites W1968354362 @default.
• W2086032237 cites W1970392387 @default.
• W2086032237 cites W1971156162 @default.
• W2086032237 cites W1984871702 @default.
• W2086032237 cites W1990162496 @default.
• W2086032237 cites W1991277245 @default.
• W2086032237 cites W1991570510 @default.
• W2086032237 cites W1992860067 @default.
• W2086032237 cites W1997876761 @default.
• W2086032237 cites W2000795392 @default.
• W2086032237 cites W2007136845 @default.
• W2086032237 cites W2009401622 @default.
• W2086032237 cites W2011375554 @default.
• W2086032237 cites W2012491715 @default.
• W2086032237 cites W2012757964 @default.
• W2086032237 cites W2014420443 @default.
• W2086032237 cites W2019594229 @default.
• W2086032237 cites W2024197930 @default.
• W2086032237 cites W2036317684 @default.
• W2086032237 cites W2043053887 @default.
• W2086032237 cites W2046451463 @default.
• W2086032237 cites W2066342049 @default.
• W2086032237 cites W2067921041 @default.
• W2086032237 cites W2068862347 @default.
• W2086032237 cites W2069936257 @default.
• W2086032237 cites W2069962033 @default.
• W2086032237 cites W2073242964 @default.
• W2086032237 cites W2073702336 @default.
• W2086032237 cites W2075206212 @default.
• W2086032237 cites W2075312583 @default.
• W2086032237 cites W2077123070 @default.
• W2086032237 cites W2086928528 @default.
• W2086032237 cites W2087167599 @default.
• W2086032237 cites W2088619634 @default.
• W2086032237 cites W2107550223 @default.
• W2086032237 cites W2115716768 @default.
• W2086032237 cites W2133488495 @default.
• W2086032237 cites W2153322977 @default.
• W2086032237 cites W2165030759 @default.
• W2086032237 cites W2187104146 @default.
• W2086032237 cites W2232549179 @default.
• W2086032237 cites W2286891291 @default.
• W2086032237 cites W2342256380 @default.
• W2086032237 cites W2408030517 @default.
• W2086032237 cites W2469298583 @default.
• W2086032237 cites W2527005417 @default.
• W2086032237 cites W386222720 @default.
• W2086032237 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13612.x" @default.
• W2086032237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175672" @default.
• W2086032237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8358559" @default.
• W2086032237 hasPublicationYear "1993" @default.
• W2086032237 type Work @default.
• W2086032237 sameAs 2086032237 @default.
• W2086032237 citedByCount "32" @default.
• W2086032237 countsByYear W20860322372014 @default.
• W2086032237 countsByYear W20860322372017 @default.
• W2086032237 countsByYear W20860322372020 @default.
• W2086032237 crossrefType "journal-article" @default.
• W2086032237 hasAuthorship W2086032237A5021736284 @default.
• W2086032237 hasAuthorship W2086032237A5031824382 @default.
• W2086032237 hasAuthorship W2086032237A5083939564 @default.
• W2086032237 hasBestOaLocation W20860322371 @default.
• W2086032237 hasConcept C126322002 @default.
• W2086032237 hasConcept C164705383 @default.
• W2086032237 hasConcept C2776331378 @default.
• W2086032237 hasConcept C2776991684 @default.
• W2086032237 hasConcept C2777953023 @default.
• W2086032237 hasConcept C2780283014 @default.
• W2086032237 hasConcept C2781005686 @default.
• W2086032237 hasConcept C39133596 @default.
• W2086032237 hasConcept C42219234 @default.
• W2086032237 hasConcept C43376680 @default.
• W2086032237 hasConcept C71924100 @default.
• W2086032237 hasConcept C84393581 @default.
• W2086032237 hasConceptScore W2086032237C126322002 @default.
• W2086032237 hasConceptScore W2086032237C164705383 @default.
• W2086032237 hasConceptScore W2086032237C2776331378 @default.
• W2086032237 hasConceptScore W2086032237C2776991684 @default.
• W2086032237 hasConceptScore W2086032237C2777953023 @default.
• W2086032237 hasConceptScore W2086032237C2780283014 @default.
• W2086032237 hasConceptScore W2086032237C2781005686 @default.
• W2086032237 hasConceptScore W2086032237C39133596 @default.
• W2086032237 hasConceptScore W2086032237C42219234 @default.
• W2086032237 hasConceptScore W2086032237C43376680 @default.
• W2086032237 hasConceptScore W2086032237C71924100 @default.
• W2086032237 hasConceptScore W2086032237C84393581 @default.
• W2086032237 hasLocation W20860322371 @default.
• W2086032237 hasLocation W20860322372 @default.
• W2086032237 hasLocation W20860322373 @default.
• W2086032237 hasLocation W20860322374 @default.
• W2086032237 hasOpenAccess W2086032237 @default.

• next