FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086032904> ?p ?o ?g. }

• W2086032904 endingPage "1110" @default.
• W2086032904 startingPage "1104" @default.
• W2086032904 abstract "Flow-mediated vasodilation and distensibility of the brachial artery in renal allograft recipients.BackgroundAlterations of large artery function and structure are frequently observed in renal allograft recipients. However, endothelial function has not yet been assessed in this population.MethodsFlow-mediated vasodilation is a useful index of endothelial function. We measured the diameter and distensibility of the brachial artery at rest using high-resolution ultrasound and Doppler frequency analysis of vessel wall movements in the M mode. Thereafter, changes in brachial artery diameter were measured during reactive hyperemia (after 4 min of forearm occlusion) in 16 cyclosporine-treated renal allograft recipients and 16 normal controls of similar age and sex ratio. Nitroglycerin-mediated vasodilation was measured to assess endothelium-independent vasodilation. Brachial artery blood pressure was measured using an automatic sphygmomanometer, and brachial artery flow was estimated using pulsed Doppler.ResultsDistensibility was reduced in renal allograft recipients (5.31 ± 0.74 vs. 9.10 ± 0.94 × 10-3/kPa, P = 0.003, mean ± SEM), while the brachial artery diameter at rest was higher (4.13 ± 0.14 vs. 3.25 ± 0.14 mm, P < 0.001). Flow-mediated vasodilation was significantly reduced in renal allograft recipients (0.13 ± 0.08 vs. 0.60 ± 0.08 mm or 3 ± 2 vs. 19 ± 3%, both P < 0.001). However, nitroglycerin-mediated vasodilation was similar in renal allograft recipients and controls (0.76 ± 0.10 vs. 0.77 ± 0.09 mm, NS, or 19 ± 3 vs. 22 ± 2%, NS). There were no significant differences in brachial artery flow at rest and during reactive hyperemia between both groups. The impairments of flow-mediated vasodilation and distensibility in renal allograft recipients remained significant after correction for serum cholesterol, creatinine, parathyroid hormone concentrations, end-diastolic diameter, as well as blood pressure levels, and were also present in eight renal allograft recipients not treated with cyclosporine. Flow-mediated vasodilation was not related to distensibility in either group.ConclusionsThe results show impaired endothelial function and reduced brachial artery distensibility in renal allograft recipients. The impairments of flow-mediated vasodilation and distensibility are not attributable to a diminished brachial artery vasodilator capacity, because endothelium-independent vasodilation was preserved in renal allograft recipients. Flow-mediated vasodilation and distensibility of the brachial artery in renal allograft recipients. Alterations of large artery function and structure are frequently observed in renal allograft recipients. However, endothelial function has not yet been assessed in this population. Flow-mediated vasodilation is a useful index of endothelial function. We measured the diameter and distensibility of the brachial artery at rest using high-resolution ultrasound and Doppler frequency analysis of vessel wall movements in the M mode. Thereafter, changes in brachial artery diameter were measured during reactive hyperemia (after 4 min of forearm occlusion) in 16 cyclosporine-treated renal allograft recipients and 16 normal controls of similar age and sex ratio. Nitroglycerin-mediated vasodilation was measured to assess endothelium-independent vasodilation. Brachial artery blood pressure was measured using an automatic sphygmomanometer, and brachial artery flow was estimated using pulsed Doppler. Distensibility was reduced in renal allograft recipients (5.31 ± 0.74 vs. 9.10 ± 0.94 × 10-3/kPa, P = 0.003, mean ± SEM), while the brachial artery diameter at rest was higher (4.13 ± 0.14 vs. 3.25 ± 0.14 mm, P < 0.001). Flow-mediated vasodilation was significantly reduced in renal allograft recipients (0.13 ± 0.08 vs. 0.60 ± 0.08 mm or 3 ± 2 vs. 19 ± 3%, both P < 0.001). However, nitroglycerin-mediated vasodilation was similar in renal allograft recipients and controls (0.76 ± 0.10 vs. 0.77 ± 0.09 mm, NS, or 19 ± 3 vs. 22 ± 2%, NS). There were no significant differences in brachial artery flow at rest and during reactive hyperemia between both groups. The impairments of flow-mediated vasodilation and distensibility in renal allograft recipients remained significant after correction for serum cholesterol, creatinine, parathyroid hormone concentrations, end-diastolic diameter, as well as blood pressure levels, and were also present in eight renal allograft recipients not treated with cyclosporine. Flow-mediated vasodilation was not related to distensibility in either group. The results show impaired endothelial function and reduced brachial artery distensibility in renal allograft recipients. The impairments of flow-mediated vasodilation and distensibility are not attributable to a diminished brachial artery vasodilator capacity, because endothelium-independent vasodilation was preserved in renal allograft recipients." @default.
• W2086032904 created "2016-06-24" @default.
• W2086032904 creator A5028175802 @default.
• W2086032904 creator A5063229551 @default.
• W2086032904 creator A5066742667 @default.
• W2086032904 creator A5070173893 @default.
• W2086032904 creator A5075048441 @default.
• W2086032904 date "1999-03-01" @default.
• W2086032904 modified "2023-09-27" @default.
• W2086032904 title "Flow-mediated vasodilation and distensibility of the brachial artery in renal allograft recipients" @default.
• W2086032904 cites W1952813734 @default.
• W2086032904 cites W1965148671 @default.
• W2086032904 cites W1968342486 @default.
• W2086032904 cites W1973377271 @default.
• W2086032904 cites W1981988093 @default.
• W2086032904 cites W1993616653 @default.
• W2086032904 cites W1994802613 @default.
• W2086032904 cites W1997262754 @default.
• W2086032904 cites W1998557358 @default.
• W2086032904 cites W2001025613 @default.
• W2086032904 cites W2001747415 @default.
• W2086032904 cites W2003667937 @default.
• W2086032904 cites W2006445996 @default.
• W2086032904 cites W2018178056 @default.
• W2086032904 cites W2036389244 @default.
• W2086032904 cites W2047451405 @default.
• W2086032904 cites W2055258815 @default.
• W2086032904 cites W2056780843 @default.
• W2086032904 cites W2058385357 @default.
• W2086032904 cites W2063506869 @default.
• W2086032904 cites W2075171387 @default.
• W2086032904 cites W2076843879 @default.
• W2086032904 cites W2080943041 @default.
• W2086032904 cites W2091366452 @default.
• W2086032904 cites W2113212881 @default.
• W2086032904 cites W2116958277 @default.
• W2086032904 cites W2118013064 @default.
• W2086032904 cites W2126862066 @default.
• W2086032904 cites W2149214262 @default.
• W2086032904 cites W2150339415 @default.
• W2086032904 cites W2157426454 @default.
• W2086032904 cites W2160772377 @default.
• W2086032904 cites W2164115669 @default.
• W2086032904 cites W2171675495 @default.
• W2086032904 cites W2315877732 @default.
• W2086032904 cites W2040296027 @default.
• W2086032904 doi "https://doi.org/10.1046/j.1523-1755.1999.0550031104.x" @default.
• W2086032904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10027950" @default.
• W2086032904 hasPublicationYear "1999" @default.
• W2086032904 type Work @default.
• W2086032904 sameAs 2086032904 @default.
• W2086032904 citedByCount "74" @default.
• W2086032904 countsByYear W20860329042012 @default.
• W2086032904 countsByYear W20860329042013 @default.
• W2086032904 countsByYear W20860329042014 @default.
• W2086032904 countsByYear W20860329042015 @default.
• W2086032904 countsByYear W20860329042017 @default.
• W2086032904 countsByYear W20860329042018 @default.
• W2086032904 countsByYear W20860329042019 @default.
• W2086032904 countsByYear W20860329042020 @default.
• W2086032904 countsByYear W20860329042021 @default.
• W2086032904 crossrefType "journal-article" @default.
• W2086032904 hasAuthorship W2086032904A5028175802 @default.
• W2086032904 hasAuthorship W2086032904A5063229551 @default.
• W2086032904 hasAuthorship W2086032904A5066742667 @default.
• W2086032904 hasAuthorship W2086032904A5070173893 @default.
• W2086032904 hasAuthorship W2086032904A5075048441 @default.
• W2086032904 hasBestOaLocation W20860329041 @default.
• W2086032904 hasConcept C120770815 @default.
• W2086032904 hasConcept C126322002 @default.
• W2086032904 hasConcept C141071460 @default.
• W2086032904 hasConcept C164705383 @default.
• W2086032904 hasConcept C2776634560 @default.
• W2086032904 hasConcept C2776820930 @default.
• W2086032904 hasConcept C2777604165 @default.
• W2086032904 hasConcept C2778218979 @default.
• W2086032904 hasConcept C2780091579 @default.
• W2086032904 hasConcept C2780214079 @default.
• W2086032904 hasConcept C2910533495 @default.
• W2086032904 hasConcept C3019128504 @default.
• W2086032904 hasConcept C71924100 @default.
• W2086032904 hasConcept C84393581 @default.
• W2086032904 hasConceptScore W2086032904C120770815 @default.
• W2086032904 hasConceptScore W2086032904C126322002 @default.
• W2086032904 hasConceptScore W2086032904C141071460 @default.
• W2086032904 hasConceptScore W2086032904C164705383 @default.
• W2086032904 hasConceptScore W2086032904C2776634560 @default.
• W2086032904 hasConceptScore W2086032904C2776820930 @default.
• W2086032904 hasConceptScore W2086032904C2777604165 @default.
• W2086032904 hasConceptScore W2086032904C2778218979 @default.
• W2086032904 hasConceptScore W2086032904C2780091579 @default.
• W2086032904 hasConceptScore W2086032904C2780214079 @default.
• W2086032904 hasConceptScore W2086032904C2910533495 @default.
• W2086032904 hasConceptScore W2086032904C3019128504 @default.
• W2086032904 hasConceptScore W2086032904C71924100 @default.
• W2086032904 hasConceptScore W2086032904C84393581 @default.
• W2086032904 hasIssue "3" @default.
• W2086032904 hasLocation W20860329041 @default.

• next